Dopaminergic neuronal responses to a non-amphetamine CNS stimulant

D. C. German, H. Harden, M. K. Sanghera, D. Mann, R. S. Kiser, H. H. Miller, P. A. Shore

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

The present study compares the effects of d-amphetamine (d-AMP) and the potent non-amphetamine CNS stimulant, amfonelic acid (AFA), on the firing rate of single midbrain dopaminergic (DA) neurons and on neostriatal DA metabolism (dihydroxyphenylacetic acid-DOPAC). The results indicate that AFA, like d-AMP, reduces the firing rate of DA neurons, although unlike d-AMP, AFA does not cause a decrease in neostriatal DOPAC content and, in fact, enhances that produced by haloperidol (HALO). The AFA-induced decrease in firing rate, like d-AMP, is reversed by the DA receptor blocker HALO, but again unlike d-AMP, the decrease in firing rate is not prevented by catecholamine synthesis inhibition with α-methyl-para-tyrosine. Thus, both amphetamine and amfonelic acid have identical electrophysiological effects on DA neurons but act by different mechanisms.

Original languageEnglish (US)
Pages (from-to)39-49
Number of pages11
JournalJournal of Neural Transmission
Volume44
Issue number1-2
DOIs
StatePublished - Mar 1 1979

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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