Dopaminergic neuronal responses to a non-amphetamine CNS stimulant

D. C. German, H. Harden, M. K. Sanghera, D. Mann, R. S. Kiser, H. H. Miller, P. A. Shore

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The present study compares the effects of d-amphetamine (d-AMP) and the potent non-amphetamine CNS stimulant, amfonelic acid (AFA), on the firing rate of single midbrain dopaminergic (DA) neurons and on neostriatal DA metabolism (dihydroxyphenylacetic acid-DOPAC). The results indicate that AFA, like d-AMP, reduces the firing rate of DA neurons, although unlike d-AMP, AFA does not cause a decrease in neostriatal DOPAC content and, in fact, enhances that produced by haloperidol (HALO). The AFA-induced decrease in firing rate, like d-AMP, is reversed by the DA receptor blocker HALO, but again unlike d-AMP, the decrease in firing rate is not prevented by catecholamine synthesis inhibition with α-methyl-para-tyrosine. Thus, both amphetamine and amfonelic acid have identical electrophysiological effects on DA neurons but act by different mechanisms.

Original languageEnglish (US)
Pages (from-to)39-49
Number of pages11
JournalJournal of Neural Transmission
Volume44
Issue number1-2
DOIs
StatePublished - Mar 1979

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Dextroamphetamine
Dopaminergic Neurons
3,4-Dihydroxyphenylacetic Acid
Haloperidol
Amphetamine
Mesencephalon
Catecholamines
Tyrosine
amfonelic acid
Acids

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

German, D. C., Harden, H., Sanghera, M. K., Mann, D., Kiser, R. S., Miller, H. H., & Shore, P. A. (1979). Dopaminergic neuronal responses to a non-amphetamine CNS stimulant. Journal of Neural Transmission, 44(1-2), 39-49. https://doi.org/10.1007/BF01252700

Dopaminergic neuronal responses to a non-amphetamine CNS stimulant. / German, D. C.; Harden, H.; Sanghera, M. K.; Mann, D.; Kiser, R. S.; Miller, H. H.; Shore, P. A.

In: Journal of Neural Transmission, Vol. 44, No. 1-2, 03.1979, p. 39-49.

Research output: Contribution to journalArticle

German, DC, Harden, H, Sanghera, MK, Mann, D, Kiser, RS, Miller, HH & Shore, PA 1979, 'Dopaminergic neuronal responses to a non-amphetamine CNS stimulant', Journal of Neural Transmission, vol. 44, no. 1-2, pp. 39-49. https://doi.org/10.1007/BF01252700
German, D. C. ; Harden, H. ; Sanghera, M. K. ; Mann, D. ; Kiser, R. S. ; Miller, H. H. ; Shore, P. A. / Dopaminergic neuronal responses to a non-amphetamine CNS stimulant. In: Journal of Neural Transmission. 1979 ; Vol. 44, No. 1-2. pp. 39-49.
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