TY - JOUR
T1 - Dopaminergic neuronal responses to a non-amphetamine CNS stimulant
AU - German, D. C.
AU - Harden, H.
AU - Sanghera, M. K.
AU - Mann, D.
AU - Kiser, R. S.
AU - Miller, H. H.
AU - Shore, P. A.
PY - 1979/3/1
Y1 - 1979/3/1
N2 - The present study compares the effects of d-amphetamine (d-AMP) and the potent non-amphetamine CNS stimulant, amfonelic acid (AFA), on the firing rate of single midbrain dopaminergic (DA) neurons and on neostriatal DA metabolism (dihydroxyphenylacetic acid-DOPAC). The results indicate that AFA, like d-AMP, reduces the firing rate of DA neurons, although unlike d-AMP, AFA does not cause a decrease in neostriatal DOPAC content and, in fact, enhances that produced by haloperidol (HALO). The AFA-induced decrease in firing rate, like d-AMP, is reversed by the DA receptor blocker HALO, but again unlike d-AMP, the decrease in firing rate is not prevented by catecholamine synthesis inhibition with α-methyl-para-tyrosine. Thus, both amphetamine and amfonelic acid have identical electrophysiological effects on DA neurons but act by different mechanisms.
AB - The present study compares the effects of d-amphetamine (d-AMP) and the potent non-amphetamine CNS stimulant, amfonelic acid (AFA), on the firing rate of single midbrain dopaminergic (DA) neurons and on neostriatal DA metabolism (dihydroxyphenylacetic acid-DOPAC). The results indicate that AFA, like d-AMP, reduces the firing rate of DA neurons, although unlike d-AMP, AFA does not cause a decrease in neostriatal DOPAC content and, in fact, enhances that produced by haloperidol (HALO). The AFA-induced decrease in firing rate, like d-AMP, is reversed by the DA receptor blocker HALO, but again unlike d-AMP, the decrease in firing rate is not prevented by catecholamine synthesis inhibition with α-methyl-para-tyrosine. Thus, both amphetamine and amfonelic acid have identical electrophysiological effects on DA neurons but act by different mechanisms.
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U2 - 10.1007/BF01252700
DO - 10.1007/BF01252700
M3 - Article
C2 - 35584
AN - SCOPUS:0018771975
SN - 0300-9564
VL - 44
SP - 39
EP - 49
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
IS - 1-2
ER -