Dose-dependency and rate of decay of efficacy of resovist on MR images in a rat cirrhotic liver model

Naoki Kato, Masaya Takahashi, Takashi Tsuji, Shinya Ihara, Matthias Brautigam, Tomoaki Miyazawa

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

RATIONALE AND OBJECTIVES. To investigate the dose-dependency and half- life of decay of the signal reduction by superparamagnetic iron oxides on three different spin-echo images in a rat model of cirrhosis. METHODS. For normal and cirrhotic liver, signal intensities were measured 15 minutes after injection of Resovist (range, 1-40 μmol Fe/kg) on three different spin-echo images. Subsequently, recovery of signal intensity was monitored up to 2 weeks after injection. RESULTS. The dose-dependency of efficacy was somewhat less at all doses and imaging parameters in cirrhotic liver. However, the submaximal effect was obtained at a dose of 20 μmol Fe/kg, the same as in normal liver. The rate of decay of the efficacy in cirrhotic liver was similar to or faster than that in normal liver. CONCLUSIONS. The dose- dependency and rate of decay of efficacy of Resovist in cirrhosis were similar to those in normal liver, although the efficacy was less in cirrhotic liver and both the dose-dependency and rate of decay of efficacy were dependent on imaging parameters.

Original languageEnglish (US)
Pages (from-to)551-557
Number of pages7
JournalInvestigative Radiology
Volume34
Issue number9
DOIs
StatePublished - Sep 1999

Fingerprint

Liver
Fibrosis
Injections
ferumoxides
Half-Life

Keywords

  • Cirrhosis
  • Contrast agent
  • Magnetic resonance
  • Rats
  • Resovist

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Dose-dependency and rate of decay of efficacy of resovist on MR images in a rat cirrhotic liver model. / Kato, Naoki; Takahashi, Masaya; Tsuji, Takashi; Ihara, Shinya; Brautigam, Matthias; Miyazawa, Tomoaki.

In: Investigative Radiology, Vol. 34, No. 9, 09.1999, p. 551-557.

Research output: Contribution to journalArticle

Kato, Naoki ; Takahashi, Masaya ; Tsuji, Takashi ; Ihara, Shinya ; Brautigam, Matthias ; Miyazawa, Tomoaki. / Dose-dependency and rate of decay of efficacy of resovist on MR images in a rat cirrhotic liver model. In: Investigative Radiology. 1999 ; Vol. 34, No. 9. pp. 551-557.
@article{79c383a4a24749d1b00fcabda374df37,
title = "Dose-dependency and rate of decay of efficacy of resovist on MR images in a rat cirrhotic liver model",
abstract = "RATIONALE AND OBJECTIVES. To investigate the dose-dependency and half- life of decay of the signal reduction by superparamagnetic iron oxides on three different spin-echo images in a rat model of cirrhosis. METHODS. For normal and cirrhotic liver, signal intensities were measured 15 minutes after injection of Resovist (range, 1-40 μmol Fe/kg) on three different spin-echo images. Subsequently, recovery of signal intensity was monitored up to 2 weeks after injection. RESULTS. The dose-dependency of efficacy was somewhat less at all doses and imaging parameters in cirrhotic liver. However, the submaximal effect was obtained at a dose of 20 μmol Fe/kg, the same as in normal liver. The rate of decay of the efficacy in cirrhotic liver was similar to or faster than that in normal liver. CONCLUSIONS. The dose- dependency and rate of decay of efficacy of Resovist in cirrhosis were similar to those in normal liver, although the efficacy was less in cirrhotic liver and both the dose-dependency and rate of decay of efficacy were dependent on imaging parameters.",
keywords = "Cirrhosis, Contrast agent, Magnetic resonance, Rats, Resovist",
author = "Naoki Kato and Masaya Takahashi and Takashi Tsuji and Shinya Ihara and Matthias Brautigam and Tomoaki Miyazawa",
year = "1999",
month = "9",
doi = "10.1097/00004424-199909000-00001",
language = "English (US)",
volume = "34",
pages = "551--557",
journal = "Investigative Radiology",
issn = "0020-9996",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Dose-dependency and rate of decay of efficacy of resovist on MR images in a rat cirrhotic liver model

AU - Kato, Naoki

AU - Takahashi, Masaya

AU - Tsuji, Takashi

AU - Ihara, Shinya

AU - Brautigam, Matthias

AU - Miyazawa, Tomoaki

PY - 1999/9

Y1 - 1999/9

N2 - RATIONALE AND OBJECTIVES. To investigate the dose-dependency and half- life of decay of the signal reduction by superparamagnetic iron oxides on three different spin-echo images in a rat model of cirrhosis. METHODS. For normal and cirrhotic liver, signal intensities were measured 15 minutes after injection of Resovist (range, 1-40 μmol Fe/kg) on three different spin-echo images. Subsequently, recovery of signal intensity was monitored up to 2 weeks after injection. RESULTS. The dose-dependency of efficacy was somewhat less at all doses and imaging parameters in cirrhotic liver. However, the submaximal effect was obtained at a dose of 20 μmol Fe/kg, the same as in normal liver. The rate of decay of the efficacy in cirrhotic liver was similar to or faster than that in normal liver. CONCLUSIONS. The dose- dependency and rate of decay of efficacy of Resovist in cirrhosis were similar to those in normal liver, although the efficacy was less in cirrhotic liver and both the dose-dependency and rate of decay of efficacy were dependent on imaging parameters.

AB - RATIONALE AND OBJECTIVES. To investigate the dose-dependency and half- life of decay of the signal reduction by superparamagnetic iron oxides on three different spin-echo images in a rat model of cirrhosis. METHODS. For normal and cirrhotic liver, signal intensities were measured 15 minutes after injection of Resovist (range, 1-40 μmol Fe/kg) on three different spin-echo images. Subsequently, recovery of signal intensity was monitored up to 2 weeks after injection. RESULTS. The dose-dependency of efficacy was somewhat less at all doses and imaging parameters in cirrhotic liver. However, the submaximal effect was obtained at a dose of 20 μmol Fe/kg, the same as in normal liver. The rate of decay of the efficacy in cirrhotic liver was similar to or faster than that in normal liver. CONCLUSIONS. The dose- dependency and rate of decay of efficacy of Resovist in cirrhosis were similar to those in normal liver, although the efficacy was less in cirrhotic liver and both the dose-dependency and rate of decay of efficacy were dependent on imaging parameters.

KW - Cirrhosis

KW - Contrast agent

KW - Magnetic resonance

KW - Rats

KW - Resovist

UR - http://www.scopus.com/inward/record.url?scp=0032821256&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032821256&partnerID=8YFLogxK

U2 - 10.1097/00004424-199909000-00001

DO - 10.1097/00004424-199909000-00001

M3 - Article

C2 - 10485069

AN - SCOPUS:0032821256

VL - 34

SP - 551

EP - 557

JO - Investigative Radiology

JF - Investigative Radiology

SN - 0020-9996

IS - 9

ER -