Abstract
RATIONALE AND OBJECTIVES. To investigate the dose-dependency and half- life of decay of the signal reduction by superparamagnetic iron oxides on three different spin-echo images in a rat model of cirrhosis. METHODS. For normal and cirrhotic liver, signal intensities were measured 15 minutes after injection of Resovist (range, 1-40 μmol Fe/kg) on three different spin-echo images. Subsequently, recovery of signal intensity was monitored up to 2 weeks after injection. RESULTS. The dose-dependency of efficacy was somewhat less at all doses and imaging parameters in cirrhotic liver. However, the submaximal effect was obtained at a dose of 20 μmol Fe/kg, the same as in normal liver. The rate of decay of the efficacy in cirrhotic liver was similar to or faster than that in normal liver. CONCLUSIONS. The dose- dependency and rate of decay of efficacy of Resovist in cirrhosis were similar to those in normal liver, although the efficacy was less in cirrhotic liver and both the dose-dependency and rate of decay of efficacy were dependent on imaging parameters.
Original language | English (US) |
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Pages (from-to) | 551-557 |
Number of pages | 7 |
Journal | Investigative Radiology |
Volume | 34 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1999 |
Keywords
- Cirrhosis
- Contrast agent
- Magnetic resonance
- Rats
- Resovist
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging