Dose distributions using kilovoltage x-rays and dose enhancement from iodine contrast agents

A. V. Mesa, A. Norman, T. D. Solberg, J. J. Demarco, J. B. Smathers

Research output: Contribution to journalArticle

88 Scopus citations

Abstract

In x-ray phototherapy of brain tumours, the tumour is loaded with iodine and exposed to kilovoltage x-rays. Due to the high photoelectric cross sections of iodine, substantial photoelectric interactions occur. The flux of photoelectrons, characteristic x-rays and Auger electrons produce a localized dose enhancement. A modified computed tomography scanner, CTRx, can be used both for tumour localization and delivery of the dose enhancement therapy. Monte Carlo methods were employed to simulate the treatment of iodinated brain tumours with a CTRx. The calculated results reveal the effect of tumour iodine concentration on dose distribution, the degree of skull bone sparing with the application of multiple arcs, and the homogeneity of tumour dose distribution versus iodine concentration. A comparison with 10 MV stereotactic radiosurgery treatment shows the potential of CTRx treatment relative to conventional treatment modalities.

Original languageEnglish (US)
Pages (from-to)1955-1968
Number of pages14
JournalPhysics in medicine and biology
Volume44
Issue number8
DOIs
StatePublished - Aug 1 1999

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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