Dose-related effects of ethanol on visual sustained attention and event-related potentials

John W. Rohrbaugh, June M. Stapleton, Raja Parasuraman, Elizabeth A. Zubovic, Henri W. Frowein, Jerald L. Varner, Bryon Adinoff, Elizabeth A. Lane, Michael J. Eckardt, Markku Linnoila

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The effects of acute ethanol intoxication on visual sustained attention were investigated in male social drinkers. Four doses ranging from 0 (placebo) to 1.05 g/kg lean body weight, with periodic maintenance dosing of 0.12 g/kg, were given in separate sessions. The task required subjects to monitor a series of blurred digits presented singly at a rate of one per sec and to respond to occasional (p=0.25) target digits with a speeded button press. Detection performance deteriorated as a function of both dose and time on task. In addition, the factors of dose and time on task interacted to produce a more rapid performance decrement under the higher doses. Early event-related potential (ERP) components (N1 and P2) were not greatly affected, suggesting that the performance decrement reflects central rather than peripheral factors. Later components related to cognitive appraisal processes (N2, P3), in contrast, varied in both amplitude and latency. Ethanol yielded dose-related delays in N2 and P3 latencies, which paralleled reaction time increases. The amplitude of N2 also decreased over time on task, and P3 amplitude decreased both as a function of dose and time on task. ERP and performance data were interpreted as demonstrating an adverse effect of ethanol on central processing capacity.

Original languageEnglish (US)
Pages (from-to)293-300
Number of pages8
JournalAlcohol
Volume4
Issue number4
DOIs
StatePublished - 1987

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Evoked Potentials
Ethanol
event
performance
intoxication
Reaction Time
body weight
Placebos
Body Weight
Maintenance
Processing
time

Keywords

  • Ethanol intoxication
  • Event-related potentials
  • Sustained attention
  • Vigilance

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Neuroscience(all)
  • Behavioral Neuroscience
  • Toxicology
  • Health(social science)

Cite this

Rohrbaugh, J. W., Stapleton, J. M., Parasuraman, R., Zubovic, E. A., Frowein, H. W., Varner, J. L., ... Linnoila, M. (1987). Dose-related effects of ethanol on visual sustained attention and event-related potentials. Alcohol, 4(4), 293-300. https://doi.org/10.1016/0741-8329(87)90026-7

Dose-related effects of ethanol on visual sustained attention and event-related potentials. / Rohrbaugh, John W.; Stapleton, June M.; Parasuraman, Raja; Zubovic, Elizabeth A.; Frowein, Henri W.; Varner, Jerald L.; Adinoff, Bryon; Lane, Elizabeth A.; Eckardt, Michael J.; Linnoila, Markku.

In: Alcohol, Vol. 4, No. 4, 1987, p. 293-300.

Research output: Contribution to journalArticle

Rohrbaugh, JW, Stapleton, JM, Parasuraman, R, Zubovic, EA, Frowein, HW, Varner, JL, Adinoff, B, Lane, EA, Eckardt, MJ & Linnoila, M 1987, 'Dose-related effects of ethanol on visual sustained attention and event-related potentials', Alcohol, vol. 4, no. 4, pp. 293-300. https://doi.org/10.1016/0741-8329(87)90026-7
Rohrbaugh JW, Stapleton JM, Parasuraman R, Zubovic EA, Frowein HW, Varner JL et al. Dose-related effects of ethanol on visual sustained attention and event-related potentials. Alcohol. 1987;4(4):293-300. https://doi.org/10.1016/0741-8329(87)90026-7
Rohrbaugh, John W. ; Stapleton, June M. ; Parasuraman, Raja ; Zubovic, Elizabeth A. ; Frowein, Henri W. ; Varner, Jerald L. ; Adinoff, Bryon ; Lane, Elizabeth A. ; Eckardt, Michael J. ; Linnoila, Markku. / Dose-related effects of ethanol on visual sustained attention and event-related potentials. In: Alcohol. 1987 ; Vol. 4, No. 4. pp. 293-300.
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abstract = "The effects of acute ethanol intoxication on visual sustained attention were investigated in male social drinkers. Four doses ranging from 0 (placebo) to 1.05 g/kg lean body weight, with periodic maintenance dosing of 0.12 g/kg, were given in separate sessions. The task required subjects to monitor a series of blurred digits presented singly at a rate of one per sec and to respond to occasional (p=0.25) target digits with a speeded button press. Detection performance deteriorated as a function of both dose and time on task. In addition, the factors of dose and time on task interacted to produce a more rapid performance decrement under the higher doses. Early event-related potential (ERP) components (N1 and P2) were not greatly affected, suggesting that the performance decrement reflects central rather than peripheral factors. Later components related to cognitive appraisal processes (N2, P3), in contrast, varied in both amplitude and latency. Ethanol yielded dose-related delays in N2 and P3 latencies, which paralleled reaction time increases. The amplitude of N2 also decreased over time on task, and P3 amplitude decreased both as a function of dose and time on task. ERP and performance data were interpreted as demonstrating an adverse effect of ethanol on central processing capacity.",
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