Background The objective of this study was to determine ED50 and ED95 of remifentanil for intubation combined with propofol in nonparalyzed Chinese children. Methods Forty-seven American Society of Anesthesiologists Class I children aged 4-11 years weighing 14-33.5 kg underwent general anesthesia with 2.5 mg·kg-1 of intravenous propofol followed by remifentanil in Wenzhou, China. The initial dose of remifentanil was 2.5 μg·kg -1 injected over 60 s. Intubation was attempted 30 s after the completion of remifentanil injection. Level of difficulty to intubate was graded on a scoring system. If the initial intubation condition was deemed satisfactory, subsequent remifentanil doses were decreased by 0.25 μg·kg-1. If the intubating condition was deemed unsatisfactory, subsequent remifentanil doses were increased by 0.25 μg·kg-1. Mean arterial pressure, heart rate, and pulse oximetry were documented before and after induction, immediately after intubation, and 1 min after intubation. Results The ED50 of remifentanil used to render a satisfactory intubating condition used in combination with 2.5 mg·kg-1 of propofol in nonparalyzed Chinese children was 2.30 μg·kg-1 (95% confidence interval: 2.28-2.31 μg·kg-1), and the ED95 is 2.75 μg·kg-1 (95% confidence interval: 2.59-3.35 μg·kg-1). These doses were lower than previously reported. Conclusion When used in combination with 2.5 mg·kg-1 of intravenous propofol, ED50 and ED95 of remifentanil for adequate intubation in nonparalyzed children were lower than previously reported, at 2.30 and 2.75 μg·kg-1, respectively.
- endotracheal intubation
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Anesthesiology and Pain Medicine