Dose requirements of remifentanil for intubation in nonparalyzed Chinese children

Hua Cheng Liu, Wei Ke Tao, Rui Feng Zeng, Wang Ning Shangguang, Jun Li, Wen Guang Huang, Zhang Lei Dong, Xin Wang, Qing Quan Lian

Research output: Contribution to journalArticle

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Abstract

Background The objective of this study was to determine ED50 and ED95 of remifentanil for intubation combined with propofol in nonparalyzed Chinese children. Methods Forty-seven American Society of Anesthesiologists Class I children aged 4-11 years weighing 14-33.5 kg underwent general anesthesia with 2.5 mg·kg-1 of intravenous propofol followed by remifentanil in Wenzhou, China. The initial dose of remifentanil was 2.5 μg·kg -1 injected over 60 s. Intubation was attempted 30 s after the completion of remifentanil injection. Level of difficulty to intubate was graded on a scoring system. If the initial intubation condition was deemed satisfactory, subsequent remifentanil doses were decreased by 0.25 μg·kg-1. If the intubating condition was deemed unsatisfactory, subsequent remifentanil doses were increased by 0.25 μg·kg-1. Mean arterial pressure, heart rate, and pulse oximetry were documented before and after induction, immediately after intubation, and 1 min after intubation. Results The ED50 of remifentanil used to render a satisfactory intubating condition used in combination with 2.5 mg·kg-1 of propofol in nonparalyzed Chinese children was 2.30 μg·kg-1 (95% confidence interval: 2.28-2.31 μg·kg-1), and the ED95 is 2.75 μg·kg-1 (95% confidence interval: 2.59-3.35 μg·kg-1). These doses were lower than previously reported. Conclusion When used in combination with 2.5 mg·kg-1 of intravenous propofol, ED50 and ED95 of remifentanil for adequate intubation in nonparalyzed children were lower than previously reported, at 2.30 and 2.75 μg·kg-1, respectively.

Original languageEnglish (US)
Pages (from-to)505-509
Number of pages5
JournalPaediatric Anaesthesia
Volume24
Issue number5
DOIs
StatePublished - 2014

Fingerprint

Intubation
Propofol
Confidence Intervals
Oximetry
remifentanil
General Anesthesia
China
Arterial Pressure
Heart Rate
Injections

Keywords

  • children
  • ED50
  • ED95
  • endotracheal intubation
  • propofol
  • remifentanil

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

Cite this

Liu, H. C., Tao, W. K., Zeng, R. F., Shangguang, W. N., Li, J., Huang, W. G., ... Lian, Q. Q. (2014). Dose requirements of remifentanil for intubation in nonparalyzed Chinese children. Paediatric Anaesthesia, 24(5), 505-509. https://doi.org/10.1111/pan.12354

Dose requirements of remifentanil for intubation in nonparalyzed Chinese children. / Liu, Hua Cheng; Tao, Wei Ke; Zeng, Rui Feng; Shangguang, Wang Ning; Li, Jun; Huang, Wen Guang; Dong, Zhang Lei; Wang, Xin; Lian, Qing Quan.

In: Paediatric Anaesthesia, Vol. 24, No. 5, 2014, p. 505-509.

Research output: Contribution to journalArticle

Liu, HC, Tao, WK, Zeng, RF, Shangguang, WN, Li, J, Huang, WG, Dong, ZL, Wang, X & Lian, QQ 2014, 'Dose requirements of remifentanil for intubation in nonparalyzed Chinese children', Paediatric Anaesthesia, vol. 24, no. 5, pp. 505-509. https://doi.org/10.1111/pan.12354
Liu, Hua Cheng ; Tao, Wei Ke ; Zeng, Rui Feng ; Shangguang, Wang Ning ; Li, Jun ; Huang, Wen Guang ; Dong, Zhang Lei ; Wang, Xin ; Lian, Qing Quan. / Dose requirements of remifentanil for intubation in nonparalyzed Chinese children. In: Paediatric Anaesthesia. 2014 ; Vol. 24, No. 5. pp. 505-509.
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abstract = "Background The objective of this study was to determine ED50 and ED95 of remifentanil for intubation combined with propofol in nonparalyzed Chinese children. Methods Forty-seven American Society of Anesthesiologists Class I children aged 4-11 years weighing 14-33.5 kg underwent general anesthesia with 2.5 mg·kg-1 of intravenous propofol followed by remifentanil in Wenzhou, China. The initial dose of remifentanil was 2.5 μg·kg -1 injected over 60 s. Intubation was attempted 30 s after the completion of remifentanil injection. Level of difficulty to intubate was graded on a scoring system. If the initial intubation condition was deemed satisfactory, subsequent remifentanil doses were decreased by 0.25 μg·kg-1. If the intubating condition was deemed unsatisfactory, subsequent remifentanil doses were increased by 0.25 μg·kg-1. Mean arterial pressure, heart rate, and pulse oximetry were documented before and after induction, immediately after intubation, and 1 min after intubation. Results The ED50 of remifentanil used to render a satisfactory intubating condition used in combination with 2.5 mg·kg-1 of propofol in nonparalyzed Chinese children was 2.30 μg·kg-1 (95{\%} confidence interval: 2.28-2.31 μg·kg-1), and the ED95 is 2.75 μg·kg-1 (95{\%} confidence interval: 2.59-3.35 μg·kg-1). These doses were lower than previously reported. Conclusion When used in combination with 2.5 mg·kg-1 of intravenous propofol, ED50 and ED95 of remifentanil for adequate intubation in nonparalyzed children were lower than previously reported, at 2.30 and 2.75 μg·kg-1, respectively.",
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AU - Liu, Hua Cheng

AU - Tao, Wei Ke

AU - Zeng, Rui Feng

AU - Shangguang, Wang Ning

AU - Li, Jun

AU - Huang, Wen Guang

AU - Dong, Zhang Lei

AU - Wang, Xin

AU - Lian, Qing Quan

PY - 2014

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N2 - Background The objective of this study was to determine ED50 and ED95 of remifentanil for intubation combined with propofol in nonparalyzed Chinese children. Methods Forty-seven American Society of Anesthesiologists Class I children aged 4-11 years weighing 14-33.5 kg underwent general anesthesia with 2.5 mg·kg-1 of intravenous propofol followed by remifentanil in Wenzhou, China. The initial dose of remifentanil was 2.5 μg·kg -1 injected over 60 s. Intubation was attempted 30 s after the completion of remifentanil injection. Level of difficulty to intubate was graded on a scoring system. If the initial intubation condition was deemed satisfactory, subsequent remifentanil doses were decreased by 0.25 μg·kg-1. If the intubating condition was deemed unsatisfactory, subsequent remifentanil doses were increased by 0.25 μg·kg-1. Mean arterial pressure, heart rate, and pulse oximetry were documented before and after induction, immediately after intubation, and 1 min after intubation. Results The ED50 of remifentanil used to render a satisfactory intubating condition used in combination with 2.5 mg·kg-1 of propofol in nonparalyzed Chinese children was 2.30 μg·kg-1 (95% confidence interval: 2.28-2.31 μg·kg-1), and the ED95 is 2.75 μg·kg-1 (95% confidence interval: 2.59-3.35 μg·kg-1). These doses were lower than previously reported. Conclusion When used in combination with 2.5 mg·kg-1 of intravenous propofol, ED50 and ED95 of remifentanil for adequate intubation in nonparalyzed children were lower than previously reported, at 2.30 and 2.75 μg·kg-1, respectively.

AB - Background The objective of this study was to determine ED50 and ED95 of remifentanil for intubation combined with propofol in nonparalyzed Chinese children. Methods Forty-seven American Society of Anesthesiologists Class I children aged 4-11 years weighing 14-33.5 kg underwent general anesthesia with 2.5 mg·kg-1 of intravenous propofol followed by remifentanil in Wenzhou, China. The initial dose of remifentanil was 2.5 μg·kg -1 injected over 60 s. Intubation was attempted 30 s after the completion of remifentanil injection. Level of difficulty to intubate was graded on a scoring system. If the initial intubation condition was deemed satisfactory, subsequent remifentanil doses were decreased by 0.25 μg·kg-1. If the intubating condition was deemed unsatisfactory, subsequent remifentanil doses were increased by 0.25 μg·kg-1. Mean arterial pressure, heart rate, and pulse oximetry were documented before and after induction, immediately after intubation, and 1 min after intubation. Results The ED50 of remifentanil used to render a satisfactory intubating condition used in combination with 2.5 mg·kg-1 of propofol in nonparalyzed Chinese children was 2.30 μg·kg-1 (95% confidence interval: 2.28-2.31 μg·kg-1), and the ED95 is 2.75 μg·kg-1 (95% confidence interval: 2.59-3.35 μg·kg-1). These doses were lower than previously reported. Conclusion When used in combination with 2.5 mg·kg-1 of intravenous propofol, ED50 and ED95 of remifentanil for adequate intubation in nonparalyzed children were lower than previously reported, at 2.30 and 2.75 μg·kg-1, respectively.

KW - children

KW - ED50

KW - ED95

KW - endotracheal intubation

KW - propofol

KW - remifentanil

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