TY - JOUR
T1 - Dose-response measures of rCBF and subjective changes following procaine in healthy female volunteers
AU - Adinoff, Bryon
AU - Devous, Michael D.
AU - Best, Susan E.
AU - Alexander, Deanna
AU - Kelly Payne, J.
AU - Williams, Mark
N1 - Funding Information:
This study was funded by NIDA grants DA10218 and DA11434, and by the Sarah and Charles E. Seay Center for Research in Psychiatric Illness.
PY - 2002/7/1
Y1 - 2002/7/1
N2 - The intravenous administration of procaine shows relatively specific activation of limbic structures. Several investigators have utilized this property of procaine to probe limbic system dysfunction in neuropsychiatric disorders. The dose of procaine utilized in human studies varies significantly, however, and the optimal dose of procaine as a limbic probe has not been demonstrated. In two 10-individual groups of healthy female volunteers, we assessed the regional cerebral blood flow (rCBF) response, by single-photon emission computed tomography (SPECT), to saline and 1.38 mg/kg procaine (Group I), and saline, 0.5 mg/kg and 1.0 mg/kg procaine (Group II). Compared to saline, 0.5 mg/kg procaine produced minimal rCBF changes, 1.0 mg/kg procaine induced both limbic and non-limbic activation, and 1.38 mg/kg procaine showed relatively specific rCBF limbic activation. Subjective responses increased in a dose-response manner. We conclude that a dose of 1.38 mg/kg procaine provides a more limited and specific activation of limbic structures than 1.00 mg/kg procaine and thus may be more useful as a specific probe of limbic function.
AB - The intravenous administration of procaine shows relatively specific activation of limbic structures. Several investigators have utilized this property of procaine to probe limbic system dysfunction in neuropsychiatric disorders. The dose of procaine utilized in human studies varies significantly, however, and the optimal dose of procaine as a limbic probe has not been demonstrated. In two 10-individual groups of healthy female volunteers, we assessed the regional cerebral blood flow (rCBF) response, by single-photon emission computed tomography (SPECT), to saline and 1.38 mg/kg procaine (Group I), and saline, 0.5 mg/kg and 1.0 mg/kg procaine (Group II). Compared to saline, 0.5 mg/kg procaine produced minimal rCBF changes, 1.0 mg/kg procaine induced both limbic and non-limbic activation, and 1.38 mg/kg procaine showed relatively specific rCBF limbic activation. Subjective responses increased in a dose-response manner. We conclude that a dose of 1.38 mg/kg procaine provides a more limited and specific activation of limbic structures than 1.00 mg/kg procaine and thus may be more useful as a specific probe of limbic function.
KW - Cocaine-related disorders
KW - Limbic system
KW - Procaine
KW - Single-photon emission computed tomography
UR - http://www.scopus.com/inward/record.url?scp=0036645749&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036645749&partnerID=8YFLogxK
U2 - 10.1016/S0925-4927(02)00008-2
DO - 10.1016/S0925-4927(02)00008-2
M3 - Article
C2 - 12113895
AN - SCOPUS:0036645749
VL - 114
SP - 123
EP - 135
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
SN - 0925-4927
IS - 3
ER -