Dosimetric verification using Monte Carlo calculations for tissue heterogeneity-corrected conformal treatment plans following RTOG 0813 dosimetric criteria for lung cancer stereotactic body radiotherapy

Jun Li, James Galvin, Amy Harrison, Robert Timmerman, Yan Yu, Ying Xiao

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Purpose: The recently activated Radiation Therapy Oncology Group (RTOG) studies of stereotactic body radiation therapy (SBRT) for non-small-cell lung cancer (NSCLC) require tissue density heterogeneity correction, where the high and intermediate dose compliance criteria were established based on superposition algorithm dose calculations. The study was aimed at comparing superposition algorithm dose calculations with Monte Carlo (MC) dose calculations for SBRT for NSCLC and to evaluate whether compliance criteria need to be adjusted for MC dose calculations. Methods and Materials: Fifteen RTOG 0236 study sets were used. The planning tumor volumes (PTV) ranged from 10.7 to 117.1 cm 3. SBRT conformal treatment plans were generated using XiO (CMS Inc.) treatment planning software with superposition algorithm to meet the dosimetric high and intermediate compliance criteria recommended by the RTOG 0813 protocol. Plans were recalculated using the MC algorithm of a Monaco (CMS, Inc.) treatment planning system. Tissue density heterogeneity correction was applied in both calculations. Results: Overall, the dosimetric quantities of the MC calculations have larger magnitudes than those of the superposition calculations. On average, R 100% (ratio of prescription isodose volume to PTV), R 50% (ratio of 50% prescription isodose volume to PTV), D 2cm (maximal dose 2 cm from PTV in any direction as a percentage of prescription dose), and V 20 (percentage of lung receiving dose equal to or larger than 20 Gy) increased by 9%, 12%, 7%, and 18%, respectively. In the superposition plans, 3 cases did not meet criteria for R 50% or D 2cm. In the MC-recalculated plans, 8 cases did not meet criteria for R 100%, R 50%, or D 2cm. After reoptimization with MC calculations, 5 cases did not meet the criteria for R 50% or D 2cm. Conclusions: Results indicate that the dosimetric criteria, e.g., the criteria for R 50% recommended by RTOG 0813 protocol, may need to be adjusted when the MC dose calculation algorithm is used.

Original languageEnglish (US)
Pages (from-to)508-513
Number of pages6
JournalInternational Journal of Radiation Oncology Biology Physics
Volume84
Issue number2
DOIs
StatePublished - Oct 1 2012

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Radiation Oncology
Radiosurgery
lungs
radiation therapy
Lung Neoplasms
Radiotherapy
cancer
dosage
planning
Tumor Burden
Compliance
Prescriptions
tumors
Non-Small Cell Lung Carcinoma
Therapeutics
Monaco
Software
Lung
computer programs

Keywords

  • Heterogeneity correction
  • Non-small-cell lung cancer
  • RTOG
  • Stereotactic body radiation therapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Cancer Research

Cite this

@article{888b25e693884e0185e8eba8599ef81b,
title = "Dosimetric verification using Monte Carlo calculations for tissue heterogeneity-corrected conformal treatment plans following RTOG 0813 dosimetric criteria for lung cancer stereotactic body radiotherapy",
abstract = "Purpose: The recently activated Radiation Therapy Oncology Group (RTOG) studies of stereotactic body radiation therapy (SBRT) for non-small-cell lung cancer (NSCLC) require tissue density heterogeneity correction, where the high and intermediate dose compliance criteria were established based on superposition algorithm dose calculations. The study was aimed at comparing superposition algorithm dose calculations with Monte Carlo (MC) dose calculations for SBRT for NSCLC and to evaluate whether compliance criteria need to be adjusted for MC dose calculations. Methods and Materials: Fifteen RTOG 0236 study sets were used. The planning tumor volumes (PTV) ranged from 10.7 to 117.1 cm 3. SBRT conformal treatment plans were generated using XiO (CMS Inc.) treatment planning software with superposition algorithm to meet the dosimetric high and intermediate compliance criteria recommended by the RTOG 0813 protocol. Plans were recalculated using the MC algorithm of a Monaco (CMS, Inc.) treatment planning system. Tissue density heterogeneity correction was applied in both calculations. Results: Overall, the dosimetric quantities of the MC calculations have larger magnitudes than those of the superposition calculations. On average, R 100{\%} (ratio of prescription isodose volume to PTV), R 50{\%} (ratio of 50{\%} prescription isodose volume to PTV), D 2cm (maximal dose 2 cm from PTV in any direction as a percentage of prescription dose), and V 20 (percentage of lung receiving dose equal to or larger than 20 Gy) increased by 9{\%}, 12{\%}, 7{\%}, and 18{\%}, respectively. In the superposition plans, 3 cases did not meet criteria for R 50{\%} or D 2cm. In the MC-recalculated plans, 8 cases did not meet criteria for R 100{\%}, R 50{\%}, or D 2cm. After reoptimization with MC calculations, 5 cases did not meet the criteria for R 50{\%} or D 2cm. Conclusions: Results indicate that the dosimetric criteria, e.g., the criteria for R 50{\%} recommended by RTOG 0813 protocol, may need to be adjusted when the MC dose calculation algorithm is used.",
keywords = "Heterogeneity correction, Non-small-cell lung cancer, RTOG, Stereotactic body radiation therapy",
author = "Jun Li and James Galvin and Amy Harrison and Robert Timmerman and Yan Yu and Ying Xiao",
year = "2012",
month = "10",
day = "1",
doi = "10.1016/j.ijrobp.2011.12.005",
language = "English (US)",
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pages = "508--513",
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publisher = "Elsevier Inc.",
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TY - JOUR

T1 - Dosimetric verification using Monte Carlo calculations for tissue heterogeneity-corrected conformal treatment plans following RTOG 0813 dosimetric criteria for lung cancer stereotactic body radiotherapy

AU - Li, Jun

AU - Galvin, James

AU - Harrison, Amy

AU - Timmerman, Robert

AU - Yu, Yan

AU - Xiao, Ying

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Purpose: The recently activated Radiation Therapy Oncology Group (RTOG) studies of stereotactic body radiation therapy (SBRT) for non-small-cell lung cancer (NSCLC) require tissue density heterogeneity correction, where the high and intermediate dose compliance criteria were established based on superposition algorithm dose calculations. The study was aimed at comparing superposition algorithm dose calculations with Monte Carlo (MC) dose calculations for SBRT for NSCLC and to evaluate whether compliance criteria need to be adjusted for MC dose calculations. Methods and Materials: Fifteen RTOG 0236 study sets were used. The planning tumor volumes (PTV) ranged from 10.7 to 117.1 cm 3. SBRT conformal treatment plans were generated using XiO (CMS Inc.) treatment planning software with superposition algorithm to meet the dosimetric high and intermediate compliance criteria recommended by the RTOG 0813 protocol. Plans were recalculated using the MC algorithm of a Monaco (CMS, Inc.) treatment planning system. Tissue density heterogeneity correction was applied in both calculations. Results: Overall, the dosimetric quantities of the MC calculations have larger magnitudes than those of the superposition calculations. On average, R 100% (ratio of prescription isodose volume to PTV), R 50% (ratio of 50% prescription isodose volume to PTV), D 2cm (maximal dose 2 cm from PTV in any direction as a percentage of prescription dose), and V 20 (percentage of lung receiving dose equal to or larger than 20 Gy) increased by 9%, 12%, 7%, and 18%, respectively. In the superposition plans, 3 cases did not meet criteria for R 50% or D 2cm. In the MC-recalculated plans, 8 cases did not meet criteria for R 100%, R 50%, or D 2cm. After reoptimization with MC calculations, 5 cases did not meet the criteria for R 50% or D 2cm. Conclusions: Results indicate that the dosimetric criteria, e.g., the criteria for R 50% recommended by RTOG 0813 protocol, may need to be adjusted when the MC dose calculation algorithm is used.

AB - Purpose: The recently activated Radiation Therapy Oncology Group (RTOG) studies of stereotactic body radiation therapy (SBRT) for non-small-cell lung cancer (NSCLC) require tissue density heterogeneity correction, where the high and intermediate dose compliance criteria were established based on superposition algorithm dose calculations. The study was aimed at comparing superposition algorithm dose calculations with Monte Carlo (MC) dose calculations for SBRT for NSCLC and to evaluate whether compliance criteria need to be adjusted for MC dose calculations. Methods and Materials: Fifteen RTOG 0236 study sets were used. The planning tumor volumes (PTV) ranged from 10.7 to 117.1 cm 3. SBRT conformal treatment plans were generated using XiO (CMS Inc.) treatment planning software with superposition algorithm to meet the dosimetric high and intermediate compliance criteria recommended by the RTOG 0813 protocol. Plans were recalculated using the MC algorithm of a Monaco (CMS, Inc.) treatment planning system. Tissue density heterogeneity correction was applied in both calculations. Results: Overall, the dosimetric quantities of the MC calculations have larger magnitudes than those of the superposition calculations. On average, R 100% (ratio of prescription isodose volume to PTV), R 50% (ratio of 50% prescription isodose volume to PTV), D 2cm (maximal dose 2 cm from PTV in any direction as a percentage of prescription dose), and V 20 (percentage of lung receiving dose equal to or larger than 20 Gy) increased by 9%, 12%, 7%, and 18%, respectively. In the superposition plans, 3 cases did not meet criteria for R 50% or D 2cm. In the MC-recalculated plans, 8 cases did not meet criteria for R 100%, R 50%, or D 2cm. After reoptimization with MC calculations, 5 cases did not meet the criteria for R 50% or D 2cm. Conclusions: Results indicate that the dosimetric criteria, e.g., the criteria for R 50% recommended by RTOG 0813 protocol, may need to be adjusted when the MC dose calculation algorithm is used.

KW - Heterogeneity correction

KW - Non-small-cell lung cancer

KW - RTOG

KW - Stereotactic body radiation therapy

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