TY - JOUR
T1 - Double-blind treatment study of shigellosis comparing ampicillin, sulfadiazine, and placebo
AU - Haltalin, Kenneth C.
AU - Nelson, John D.
AU - Ring, Robert
AU - Sladoje, Mildred
AU - Hinton, Lula V.
N1 - Funding Information:
Diarrheal Disease Study Unit, Department of Pediatrics, The University of Texas Southwestern Medical School. Supported by the John A. Hartford Foundation and also, in part, by Ayerst Laboratories. Presented in part at the Sixth Interscience Conference on Antimicrobial Agents and Chemotherapy, Philadelphia, October 27, 1966.
PY - 1967/6
Y1 - 1967/6
N2 - A double-blind treatment study comparing ampicillin, sulfadiazine, and placebo was performed in 52 infants and children hospitalized for shigellosis. Bacteriological failure rates in patients treated with placebo and sulfadiazine were 75 per cent and 39 per cent, respectively, compared with 6 per cent in ampicillin-treated patients. Clinical failure occurred in 56 per cent of patients treated with placebo, 39 per cent in sulfadiazine-treated patients and in none of the patients who received ampicillin. Ampicillin is a safe and highly effective drug for the treatment of shigellosis.
AB - A double-blind treatment study comparing ampicillin, sulfadiazine, and placebo was performed in 52 infants and children hospitalized for shigellosis. Bacteriological failure rates in patients treated with placebo and sulfadiazine were 75 per cent and 39 per cent, respectively, compared with 6 per cent in ampicillin-treated patients. Clinical failure occurred in 56 per cent of patients treated with placebo, 39 per cent in sulfadiazine-treated patients and in none of the patients who received ampicillin. Ampicillin is a safe and highly effective drug for the treatment of shigellosis.
UR - http://www.scopus.com/inward/record.url?scp=0014093470&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0014093470&partnerID=8YFLogxK
U2 - 10.1016/S0022-3476(67)80275-0
DO - 10.1016/S0022-3476(67)80275-0
M3 - Article
C2 - 5338090
AN - SCOPUS:0014093470
SN - 0022-3476
VL - 70
SP - 970
EP - 981
JO - The Journal of pediatrics
JF - The Journal of pediatrics
IS - 6
ER -