A double-blind treatment study comparing ampicillin, sulfadiazine, and placebo was performed in 52 infants and children hospitalized for shigellosis. Bacteriological failure rates in patients treated with placebo and sulfadiazine were 75 per cent and 39 per cent, respectively, compared with 6 per cent in ampicillin-treated patients. Clinical failure occurred in 56 per cent of patients treated with placebo, 39 per cent in sulfadiazine-treated patients and in none of the patients who received ampicillin. Ampicillin is a safe and highly effective drug for the treatment of shigellosis.
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health