Double Cycloisomerization as a Novel and Expeditious Route to Tricyclic Heteroaromatic Compounds: Short and Highly Diastereoselective Synthesis of (±)-Tetraponerine T6

Joseph T. Kim, Vladimir Gevorgyan

Research output: Contribution to journalArticle

77 Scopus citations

Abstract

(Matrix Presented) Cu-Assisted double cycloisomerization of bis-alkynylpyrimidines afforded the 5-6-5 tricyclic heteroaromatic skeleton. This transformation was used as a key step in the highly diastereoselective total synthesis of (±)-tetraponerine T6.

Original languageEnglish (US)
Pages (from-to)4697-4699
Number of pages3
JournalOrganic Letters
Volume4
Issue number26
DOIs
StatePublished - Dec 26 2002
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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