Double filtration plasmapheresis for the treatment of bullous pemphigoid: A three case report

Yukiko Kitabata, Mikihisa Sakurane, Hikari Orita, Motohiro Kamimura, Kazuhiro Siizaki, Nobuhiko Narukawa, Akio Kaketaka, Takaya Abe, Hirotugu Kobata, Tadao Akizawa

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Bullous pemphigoid (BP) is an autoimmune disease caused by an antidermal basal lamina antibody. In recent years double filtration plasmapheresis (DFPP) has been reported to be an effective therapy for BP. We experienced 3 cases of BP treated by DFPP. DFPP resulted in an improvement in clinical symptoms and remission allowing a decrease in the required dose of corticosteroid. DFPP was found to be an effective treatment for all 3 patients without noticeable adverse events resulting from DFPP. From these results it is concluded that DFPP is worth considering as an option as treatment for BP patients who were unresponsive to conventional steroid therapy, those in whom corticosteroids should be reduced or discontinued because of complications such as diabetes mellitus and/or osteoporosis.

Original languageEnglish (US)
Pages (from-to)484-490
Number of pages7
JournalTherapeutic Apheresis
Volume5
Issue number6
DOIs
StatePublished - 2001

Keywords

  • Antidermal basal lamina antibody
  • Autoimmune dermal disease
  • Bullous pemphigoid
  • Double filtration plasmapheresis
  • Plasma exchange

ASJC Scopus subject areas

  • Medicine(all)

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