Double filtration plasmapheresis for the treatment of bullous pemphigoid: A three case report

Yukiko Kitabata; Mikihisa Sakurane; Hikari Orita; Motohiro Kamimura; Kazuhiro Siizaki; Nobuhiko Narukawa; Akio Kaketaka; Takaya Abe; Hirotugu Kobata; Tadao Akizawa

doi:10.1046/j.1526-0968.2001.00399.x

Double filtration plasmapheresis for the treatment of bullous pemphigoid: A three case report

Yukiko Kitabata, Mikihisa Sakurane, Hikari Orita, Motohiro Kamimura, Kazuhiro Siizaki, Nobuhiko Narukawa, Akio Kaketaka, Takaya Abe, Hirotugu Kobata, Tadao Akizawa

Pathology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Bullous pemphigoid (BP) is an autoimmune disease caused by an antidermal basal lamina antibody. In recent years double filtration plasmapheresis (DFPP) has been reported to be an effective therapy for BP. We experienced 3 cases of BP treated by DFPP. DFPP resulted in an improvement in clinical symptoms and remission allowing a decrease in the required dose of corticosteroid. DFPP was found to be an effective treatment for all 3 patients without noticeable adverse events resulting from DFPP. From these results it is concluded that DFPP is worth considering as an option as treatment for BP patients who were unresponsive to conventional steroid therapy, those in whom corticosteroids should be reduced or discontinued because of complications such as diabetes mellitus and/or osteoporosis.

Original language	English (US)
Pages (from-to)	484-490
Number of pages	7
Journal	Therapeutic Apheresis
Volume	5
Issue number	6
DOIs	https://doi.org/10.1046/j.1526-0968.2001.00399.x
State	Published - 2001

Keywords

Antidermal basal lamina antibody
Autoimmune dermal disease
Bullous pemphigoid
Double filtration plasmapheresis
Plasma exchange

ASJC Scopus subject areas

General Medicine

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10.1046/j.1526-0968.2001.00399.x

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title = "Double filtration plasmapheresis for the treatment of bullous pemphigoid: A three case report",

abstract = "Bullous pemphigoid (BP) is an autoimmune disease caused by an antidermal basal lamina antibody. In recent years double filtration plasmapheresis (DFPP) has been reported to be an effective therapy for BP. We experienced 3 cases of BP treated by DFPP. DFPP resulted in an improvement in clinical symptoms and remission allowing a decrease in the required dose of corticosteroid. DFPP was found to be an effective treatment for all 3 patients without noticeable adverse events resulting from DFPP. From these results it is concluded that DFPP is worth considering as an option as treatment for BP patients who were unresponsive to conventional steroid therapy, those in whom corticosteroids should be reduced or discontinued because of complications such as diabetes mellitus and/or osteoporosis.",

keywords = "Antidermal basal lamina antibody, Autoimmune dermal disease, Bullous pemphigoid, Double filtration plasmapheresis, Plasma exchange",

author = "Yukiko Kitabata and Mikihisa Sakurane and Hikari Orita and Motohiro Kamimura and Kazuhiro Siizaki and Nobuhiko Narukawa and Akio Kaketaka and Takaya Abe and Hirotugu Kobata and Tadao Akizawa",

year = "2001",

doi = "10.1046/j.1526-0968.2001.00399.x",

language = "English (US)",

volume = "5",

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journal = "Therapeutic Apheresis",

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T1 - Double filtration plasmapheresis for the treatment of bullous pemphigoid

T2 - A three case report

AU - Kitabata, Yukiko

AU - Sakurane, Mikihisa

AU - Orita, Hikari

AU - Kamimura, Motohiro

AU - Siizaki, Kazuhiro

AU - Narukawa, Nobuhiko

AU - Kaketaka, Akio

AU - Abe, Takaya

AU - Kobata, Hirotugu

AU - Akizawa, Tadao

PY - 2001

Y1 - 2001

N2 - Bullous pemphigoid (BP) is an autoimmune disease caused by an antidermal basal lamina antibody. In recent years double filtration plasmapheresis (DFPP) has been reported to be an effective therapy for BP. We experienced 3 cases of BP treated by DFPP. DFPP resulted in an improvement in clinical symptoms and remission allowing a decrease in the required dose of corticosteroid. DFPP was found to be an effective treatment for all 3 patients without noticeable adverse events resulting from DFPP. From these results it is concluded that DFPP is worth considering as an option as treatment for BP patients who were unresponsive to conventional steroid therapy, those in whom corticosteroids should be reduced or discontinued because of complications such as diabetes mellitus and/or osteoporosis.

AB - Bullous pemphigoid (BP) is an autoimmune disease caused by an antidermal basal lamina antibody. In recent years double filtration plasmapheresis (DFPP) has been reported to be an effective therapy for BP. We experienced 3 cases of BP treated by DFPP. DFPP resulted in an improvement in clinical symptoms and remission allowing a decrease in the required dose of corticosteroid. DFPP was found to be an effective treatment for all 3 patients without noticeable adverse events resulting from DFPP. From these results it is concluded that DFPP is worth considering as an option as treatment for BP patients who were unresponsive to conventional steroid therapy, those in whom corticosteroids should be reduced or discontinued because of complications such as diabetes mellitus and/or osteoporosis.

KW - Antidermal basal lamina antibody

KW - Autoimmune dermal disease

KW - Bullous pemphigoid

KW - Double filtration plasmapheresis

KW - Plasma exchange

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DO - 10.1046/j.1526-0968.2001.00399.x

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Double filtration plasmapheresis for the treatment of bullous pemphigoid: A three case report

Abstract

Keywords

ASJC Scopus subject areas

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