Double-Stranded RNA Sensing Determines Epithelial Cell Identity

Chung Ping Liao Ph.D., Edem Tchegnon, Lu Q Le

Research output: Contribution to journalComment/debatepeer-review

Abstract

Skin epithelium is constituted by heterogeneous keratinocytes in different body areas. In this issue, Zhou et al. used transcriptome analysis to investigate the site-specific epidermal cell identity on volar skin. Keratin 9 is highly enriched in volar keratinocytes, and its expression is dependent on low expression of the double-stranded RNA receptor DDX58, suggesting that double-stranded RNA sensing could allow a potential approach to modulate skin thickness and durability.

Original languageEnglish (US)
Pages (from-to)17-19
Number of pages3
JournalJournal of Investigative Dermatology
Volume139
Issue number1
DOIs
StatePublished - Jan 2019

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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