TY - JOUR
T1 - Double-Stranded RNA Sensing Determines Epithelial Cell Identity
AU - Liao Ph.D., Chung Ping
AU - Tchegnon, Edem
AU - Le, Lu Q
N1 - Funding Information:
CPL is a recipient of the Career Development Award from the Dermatology Foundation. LQL holds a Career Award for Medical Scientists from the Burroughs Wellcome Fund and the Thomas L. Shield, MD Professorship in Dermatology and is supported by funding from the National Cancer Institute of the National Institutes of Health and the US Department of Defense .
Funding Information:
CPL is a recipient of the Career Development Award from the Dermatology Foundation. LQL holds a Career Award for Medical Scientists from the Burroughs Wellcome Fund and the Thomas L. Shield, MD Professorship in Dermatology and is supported by funding from the National Cancer Institute of the National Institutes of Health and the US Department of Defense.
Publisher Copyright:
© 2018 The Authors
PY - 2019/1
Y1 - 2019/1
N2 - Skin epithelium is constituted by heterogeneous keratinocytes in different body areas. In this issue, Zhou et al. used transcriptome analysis to investigate the site-specific epidermal cell identity on volar skin. Keratin 9 is highly enriched in volar keratinocytes, and its expression is dependent on low expression of the double-stranded RNA receptor DDX58, suggesting that double-stranded RNA sensing could allow a potential approach to modulate skin thickness and durability.
AB - Skin epithelium is constituted by heterogeneous keratinocytes in different body areas. In this issue, Zhou et al. used transcriptome analysis to investigate the site-specific epidermal cell identity on volar skin. Keratin 9 is highly enriched in volar keratinocytes, and its expression is dependent on low expression of the double-stranded RNA receptor DDX58, suggesting that double-stranded RNA sensing could allow a potential approach to modulate skin thickness and durability.
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U2 - 10.1016/j.jid.2018.08.008
DO - 10.1016/j.jid.2018.08.008
M3 - Comment/debate
C2 - 30579424
AN - SCOPUS:85056739688
SN - 0022-202X
VL - 139
SP - 17
EP - 19
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 1
ER -