Down regulation of oxidative phosphorylation in Alzheimer disease: Loss of cytochrome oxidase subunit mRNA in the hippocampus and entorhinal cortex

Krish Chandrasekaran, Kimmo Hatanpää, Daniel R. Brady, James Stoll, Stanley I. Rapoport

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Messenger RNA (mRNA) for cytochrome oxidase subunit II (COX II) was localized by in situ hybridization in the entorhinal cortex and hippocampal formation of postmortem brain tissue from normal human subjects and from patients with Alzheimer disease (AD). In the control entorhinal cortex, COX II mRNA was detected mainly in neuronal cell bodies of layers II and IV. In control hippocampal formation, highest levels were localized in neuronal cell bodies of the dentate gyrus and the CA3 and CA1 regions, neurons that are involved in the major input and output pathways of the hippocampal formation. In AD brain, COX II mRNA was markedly reduced in the entorhinal cortex and the hippocampal formation compared with control brain. In the AD hippocampal formation, reductions were in regions severely affected by AD pathology as well as in regions that were relatively spared. These results are consistent with the hypothesis that reduced mitochondrial energy metabolism reflects loss of neuronal connections in AD.

Original languageEnglish (US)
Pages (from-to)13-19
Number of pages7
JournalBrain Research
Volume796
Issue number1-2
DOIs
StatePublished - Jun 15 1998

Keywords

  • Mitochondria
  • Mitochondrial DNA
  • Mutation
  • Neuritic plaque
  • Neurofibrillary tangles
  • Neuronal activity
  • Oxidative damage
  • Synapse

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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