Abstract
MDA-468 human breast cancer cells overexpress the EGFR and exhibit a functional TGFα-EGFR autocrine pathway. Loss of EGFR expression following stable transfection with an antisense EGFR cDNA containing plasmid down-regulates type T cAMP-dependent protein kinase (PKAI) expression with acquisition of cell growth resistance to the PKAI inhibitor 8-Cl-cAMP. These results suggest that PKAI expression and function are controlled by a TGFα-EGFR autocrine pathway in human breast cancer cells overexpressing the EGFR.
Original language | English (US) |
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Pages (from-to) | 57-62 |
Number of pages | 6 |
Journal | Breast Cancer Research and Treatment |
Volume | 47 |
Issue number | 1 |
DOIs | |
State | Published - 1998 |
Keywords
- Antisense
- Growth factors
- Receptors
ASJC Scopus subject areas
- Oncology
- Cancer Research