Doxorubicin cardiomyopathy in children with left-sided Wilms tumor

D. Pinkel, B. Camitta, L. Kun, C. Howarth, T. Tang

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Two children with Wilms tumor of the left kidney experienced severe anthracycline cardiomyopathy after irradiation to the tumor bed and conventional dosage of doxorubicin. The cardiomyopathy is attributed 1) to the fact that radiation fields for left Wilms tumor include the lower portion of the heart and 2) to the interaction of doxorubicin and irradiation on cardiac muscle. It is recommended that doxorubicin dosage be sharply restricted in children with Wilms tumor of the left kidney who receive postoperative irradiation.

Original languageEnglish (US)
Pages (from-to)483-488
Number of pages6
JournalMedical and Pediatric Oncology
Volume10
Issue number5
StatePublished - 1982

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

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