Drak2 is not required for tumor surveillance and suppression

Benjamin A. Edwards, Tarsha L. Harris, Helen Floersh, John R. Lukens, Md Hasan Zaki, Peter Vogel, Thirumala Devi Kanneganti, Jack D. Bui, Maureen A. McGargill

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Drak2 is a promising therapeutic target to treat organ-specific autoimmune diseases such as type 1 diabetes and multiple sclerosis without causing generalized immune suppression. Inhibition of Drak2 may also prevent graft rejection following organ transplantation. However, Drak2 may function as a critical tumor suppressor, which would challenge the prospect of targeting Drak2 for therapeutic treatment. Thus, we examined the susceptibility of Drak2<sup>-/-</sup> mice in several tumor models. We show that Drak2 is not required to prevent tumor formation in a variety of settings. Therefore, Drak2 does not function as an essential tumor suppressor in in vivo tumor models. These data further validate Drak2 as a viable therapeutic target to treat autoimmune disease and graft rejection. Importantly, these data also indicate that while Drak2 may induce apoptosis when overexpressed in cell lines, it is not an essential tumor suppressor.

Original languageEnglish (US)
Pages (from-to)161-166
Number of pages6
JournalInternational Immunology
Volume27
Issue number3
DOIs
StatePublished - 2015

Keywords

  • Autoimmunity
  • Regulation of immune responses
  • Tumor surveillance

ASJC Scopus subject areas

  • Immunology

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  • Cite this

    Edwards, B. A., Harris, T. L., Floersh, H., Lukens, J. R., Zaki, M. H., Vogel, P., Kanneganti, T. D., Bui, J. D., & McGargill, M. A. (2015). Drak2 is not required for tumor surveillance and suppression. International Immunology, 27(3), 161-166. https://doi.org/10.1093/intimm/dxu146