Draxin, a repulsive axon guidance protein, is involved in hippocampal development

Sanbing Zhang, Yuhong Su, Yohei Shinmyo, Shahidul M. Islam, Iftekhar Bin Naser, Giasuddin Ahmed, Nobuaki Tamamaki, Hideaki Tanaka

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Abstract

The hippocampus plays an essential role in learning and memory and is one of the major sites implicated in neural diseases. The proper organization of the hippocampus during development is important for its function. We found that draxin, a repulsive axon guidance cue, was widely expressed in the developing hippocampus and draxin deficient mice possessed a smaller hippocampus, particularly in the anterior part of the structure. Quantification of this reduction revealed that the volume of the dentate gyrus of the mutant was significantly smaller compared to the normal counterpart. This size reduction seemed to be dependent on apoptosis rather than due to a decrease in the rate of cell division.

Original languageEnglish (US)
Pages (from-to)53-61
Number of pages9
JournalNeuroscience Research
Volume66
Issue number1
DOIs
StatePublished - Jan 1 2010

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Keywords

  • Cell death
  • Dentate gyrus
  • Draxin
  • Hippocampus
  • Knockout mouse
  • Repulsive axon guidance protein

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Zhang, S., Su, Y., Shinmyo, Y., Islam, S. M., Naser, I. B., Ahmed, G., Tamamaki, N., & Tanaka, H. (2010). Draxin, a repulsive axon guidance protein, is involved in hippocampal development. Neuroscience Research, 66(1), 53-61. https://doi.org/10.1016/j.neures.2009.09.1710