dRGS7 encodes a Drosophila homolog of EGL-10 and vertebrate RGS7

Tamara Elmore, Antony Rodriguez, Dean P. Smith

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We identified a Drosophila gene encoding a homolog of the regulator of G-protein signaling (RGS) protein family. This gene (dRGS7) is expressed in neurons of the embryo and adult fly and is predicted to encode a 428-amino acid protein with >55% overall amino acid sequence identity with the vertebrate protein RGS7 and the C. elegans EGL-10. The dRGS7 protein is 50% conserved in the C-terminal RGS domain with RGS7 and EGL-10 but, remarkably, displays much greater conservation with the N-terminal regions of these proteins. This finding implies a conserved function for these homologs from divergent species involving domains outside the RGS domain. The dRGS7 protein also has a domain of similarity with Dishevelled and pleckstrin, raising the possibility that these proteins interact with common signaling components.

Original languageEnglish (US)
Pages (from-to)983-989
Number of pages7
JournalDNA and Cell Biology
Volume17
Issue number11
DOIs
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

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