Drivers of EMT and immune evasion

Rolf A. Brekken, Katarzyna Wnuk-Lipinska

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The heterogeneity of tumor cells and the complexity of the surrounding microenvironment make the process of predicting patient outcome and selection of the most suitable treatment regimen very difficult. Over the past decades, many biomarkers have been evaluated for prognostic value. The advent of immune therapy as a frontline treatment for some cancers has moved immune phenotyping into the forefront of biomarker and predictive marker research. Here, we review some of the regulatory mechanisms of the host immune response and epithelial plasticity and highlight their potential as biomarkers of the hallmark of immune evasion.

Original languageEnglish (US)
Title of host publicationBiomarkers of the Tumor Microenvironment
Subtitle of host publicationBasic Studies and Practical Applications
PublisherSpringer International Publishing
Pages221-239
Number of pages19
ISBN (Electronic)9783319391472
ISBN (Print)9783319391458
DOIs
StatePublished - Aug 2 2017

Keywords

  • EMT
  • Immunosuppression
  • Inflammation
  • Phosphatidylserine
  • TAM receptors

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Drivers of EMT and immune evasion'. Together they form a unique fingerprint.

  • Cite this

    Brekken, R. A., & Wnuk-Lipinska, K. (2017). Drivers of EMT and immune evasion. In Biomarkers of the Tumor Microenvironment: Basic Studies and Practical Applications (pp. 221-239). Springer International Publishing. https://doi.org/10.1007/978-3-319-39147-2_9