Drosophila fasciclinII is required for the formation of odor memories and for normal sensitivity to alcohol

Yuzhong Cheng, Keita Endo, Kwok Wu, Aylin R. Rodan, Ulrike Heberlein, Ronald L. Davis

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Drosophila fasciclinII (fasII) mutants perform poorly after olfactory conditioning due to a defect in encoding, stabilizing, or retrieving short-term memories. Performance was rescued by inducing the expression of a normal transgene just before training and immediate testing. Induction after training but before testing failed to rescue performance, showing that Fas II does not have an exclusive role in memory retrieval processes. The stability of odor memories in fasII mutants are indistinguishable from control animals when initial performance is normalized. Like several other mutants deficient in odor learning, fasII mutants exhibit a heightened sensitivity to ethanol vapors. A combination of behavioral and genetic strategies have therefore revealed a role for Fas II in the molecular operations of encoding short-term odor memories and conferring alcohol sensitivity. The preferential expression of Fas II in the axons of mushroom body neurons furthermore suggests that short-term odor memories are formed in these neurites.

Original languageEnglish (US)
Pages (from-to)757-768
Number of pages12
JournalCell
Volume105
Issue number6
DOIs
StatePublished - Jun 15 2001

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Odors
Drosophila
Short-Term Memory
Alcohols
Data storage equipment
Mushroom Bodies
Behavioral Genetics
Neurites
Transgenes
Axons
Testing
Ethanol
Neurons
Learning
Animals
Vapors
Odorants
Defects

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Drosophila fasciclinII is required for the formation of odor memories and for normal sensitivity to alcohol. / Cheng, Yuzhong; Endo, Keita; Wu, Kwok; Rodan, Aylin R.; Heberlein, Ulrike; Davis, Ronald L.

In: Cell, Vol. 105, No. 6, 15.06.2001, p. 757-768.

Research output: Contribution to journalArticle

Cheng, Yuzhong ; Endo, Keita ; Wu, Kwok ; Rodan, Aylin R. ; Heberlein, Ulrike ; Davis, Ronald L. / Drosophila fasciclinII is required for the formation of odor memories and for normal sensitivity to alcohol. In: Cell. 2001 ; Vol. 105, No. 6. pp. 757-768.
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