Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes

Rupali Ugrankar, Jade Bowerman, Hanaa Hariri, Mintu Chandra, Kevin Chen, Marie France Bossanyi, Sanchari Datta, Sean Rogers, Kaitlyn M. Eckert, Goncalo Dias do Vale, Alexia Victoria, Joseph Fresquez, Jeffrey G McDonald, Steve Jean, Brett M. Collins, William M Henne

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Adipocytes store fat in lipid droplets (LDs), but how this is organized remains unclear. Ugrankar et al. show that Drosophila adipocytes organize their LDs into spatially and functionally distinct sub-populations. Snazarus localizes to ER-PM contacts and binds to peripheral LDs to regulate fat storage, and influences fly health and lifespan.

Original languageEnglish (US)
Pages (from-to)557-572.e5
JournalDevelopmental Cell
Volume50
Issue number5
DOIs
StatePublished - Sep 9 2019

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Keywords

  • Drosophila fat body
  • endoplasmic reticulum
  • ER
  • ER-PM contact site
  • FA
  • fatty acid
  • FB
  • LD
  • lipid droplet
  • plasma membrane
  • PM

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

Cite this

Ugrankar, R., Bowerman, J., Hariri, H., Chandra, M., Chen, K., Bossanyi, M. F., Datta, S., Rogers, S., Eckert, K. M., Dias do Vale, G., Victoria, A., Fresquez, J., McDonald, J. G., Jean, S., Collins, B. M., & Henne, W. M. (2019). Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes. Developmental Cell, 50(5), 557-572.e5. https://doi.org/10.1016/j.devcel.2019.07.021