Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes

Rupali Ugrankar, Jade Bowerman, Hanaa Hariri, Mintu Chandra, Kevin Chen, Marie France Bossanyi, Sanchari Datta, Sean Rogers, Kaitlyn M. Eckert, Goncalo Dias do Vale, Alexia Victoria, Joseph Fresquez, Jeffrey G McDonald, Steve Jean, Brett M. Collins, William M Henne

Research output: Contribution to journalArticle

Abstract

Adipocytes store fat in lipid droplets (LDs), but how this is organized remains unclear. Ugrankar et al. show that Drosophila adipocytes organize their LDs into spatially and functionally distinct sub-populations. Snazarus localizes to ER-PM contacts and binds to peripheral LDs to regulate fat storage, and influences fly health and lifespan.

Original languageEnglish (US)
Pages (from-to)557-572.e5
JournalDevelopmental Cell
Volume50
Issue number5
DOIs
StatePublished - Sep 9 2019

Fingerprint

Cell membranes
Adipocytes
Contacts (fluid mechanics)
Drosophila
Cell Membrane
Lipids
Fats
Population
Health
Lipid Droplets

Keywords

  • Drosophila fat body
  • endoplasmic reticulum
  • ER
  • ER-PM contact site
  • FA
  • fatty acid
  • FB
  • LD
  • lipid droplet
  • plasma membrane
  • PM

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

Cite this

Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes. / Ugrankar, Rupali; Bowerman, Jade; Hariri, Hanaa; Chandra, Mintu; Chen, Kevin; Bossanyi, Marie France; Datta, Sanchari; Rogers, Sean; Eckert, Kaitlyn M.; Dias do Vale, Goncalo; Victoria, Alexia; Fresquez, Joseph; McDonald, Jeffrey G; Jean, Steve; Collins, Brett M.; Henne, William M.

In: Developmental Cell, Vol. 50, No. 5, 09.09.2019, p. 557-572.e5.

Research output: Contribution to journalArticle

Ugrankar, R, Bowerman, J, Hariri, H, Chandra, M, Chen, K, Bossanyi, MF, Datta, S, Rogers, S, Eckert, KM, Dias do Vale, G, Victoria, A, Fresquez, J, McDonald, JG, Jean, S, Collins, BM & Henne, WM 2019, 'Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes', Developmental Cell, vol. 50, no. 5, pp. 557-572.e5. https://doi.org/10.1016/j.devcel.2019.07.021
Ugrankar, Rupali ; Bowerman, Jade ; Hariri, Hanaa ; Chandra, Mintu ; Chen, Kevin ; Bossanyi, Marie France ; Datta, Sanchari ; Rogers, Sean ; Eckert, Kaitlyn M. ; Dias do Vale, Goncalo ; Victoria, Alexia ; Fresquez, Joseph ; McDonald, Jeffrey G ; Jean, Steve ; Collins, Brett M. ; Henne, William M. / Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes. In: Developmental Cell. 2019 ; Vol. 50, No. 5. pp. 557-572.e5.
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