Abstract
Drug allergy is one type of adverse reaction to drugs and encompasses a spectrum of hypersensitivity reactions with heterogeneous mechanisms and clinical presentations. A thorough history is essential to the management of drug allergy. Laboratory testing has a very limited role in the management of drug allergy. Graded dose challenges and procedures to induce drug tolerance might be required in patients with drug allergy when there is a definite need for a particular agent. Management of reactions to specific agents, including β-lactam antibiotics, sulfonamides, local anesthetics, radiocontrast media, angiotensin-converting enzyme inhibitors, nonsteroidal anti-inflammatory drugs, and biologic modifiers, will be discussed in further detail.
| Original language | English (US) |
|---|---|
| Pages (from-to) | S126-S137.e1 |
| Journal | Journal of Allergy and Clinical Immunology |
| Volume | 125 |
| Issue number | 2 SUPPL. 2 |
| DOIs | |
| State | Published - Feb 2010 |
Keywords
- Drug allergy
- adverse drug reactions
- angiotensin-converting enzyme inhibitors
- biologic modifiers
- carbapenem
- cephalosporin
- desensitization
- drug hypersensitivity
- graded challenge
- local anesthetic
- nonsteroidal anti-inflammatory drug
- penicillin
- radiocontrast media
- sulfonamide
- tolerance
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology