Drug allergy

David A. Khan, Roland Solensky

Research output: Contribution to journalArticle

140 Scopus citations

Abstract

Drug allergy is one type of adverse reaction to drugs and encompasses a spectrum of hypersensitivity reactions with heterogeneous mechanisms and clinical presentations. A thorough history is essential to the management of drug allergy. Laboratory testing has a very limited role in the management of drug allergy. Graded dose challenges and procedures to induce drug tolerance might be required in patients with drug allergy when there is a definite need for a particular agent. Management of reactions to specific agents, including β-lactam antibiotics, sulfonamides, local anesthetics, radiocontrast media, angiotensin-converting enzyme inhibitors, nonsteroidal anti-inflammatory drugs, and biologic modifiers, will be discussed in further detail.

Original languageEnglish (US)
Pages (from-to)S126-S137.e1
JournalJournal of Allergy and Clinical Immunology
Volume125
Issue number2 SUPPL. 2
DOIs
StatePublished - Feb 2010

Keywords

  • Drug allergy
  • adverse drug reactions
  • angiotensin-converting enzyme inhibitors
  • biologic modifiers
  • carbapenem
  • cephalosporin
  • desensitization
  • drug hypersensitivity
  • graded challenge
  • local anesthetic
  • nonsteroidal anti-inflammatory drug
  • penicillin
  • radiocontrast media
  • sulfonamide
  • tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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