Drug-Coated Balloon and Stent Therapies for Endovascular Treatment of Atherosclerotic Superficial Femoral Artery Disease

Subhash Banerjee, Karan Sarode, Atif Mohammad, Emmanouil S. Brilakis

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Endovascular management of superficial femoral artery disease has historically been limited to percutaneous balloon angioplasty, atherectomy, and bare-metal stents. However, these therapies have been plagued by high restenosis and target lesion revascularization rates. More recent technologies such as drug-coated stents and balloons are designed to combat restenosis by locally delivering antiproliferative drugs. Several randomized controlled trials have directly compared these antiproliferative drug-delivering devices to their non-drug-coated counterparts. Additionally, trials are currently ongoing to compare use of drug-coated technologies in combination with traditional therapies in hope of synergistic effects. This review gathers data from currently published clinical trials, provides an overview of upcoming clinical studies utilizing drug-coated technology, and explores the possible impact these devices may have on clinical practice.

Original languageEnglish (US)
JournalCurrent Cardiology Reports
Volume17
Issue number5
DOIs
StatePublished - May 1 2015

Fingerprint

Drug-Eluting Stents
Femoral Artery
Technology
Pharmaceutical Preparations
Atherectomy
Equipment and Supplies
Balloon Angioplasty
Therapeutics
Stents
Meta-Analysis
Randomized Controlled Trials
Metals

Keywords

  • Chronic total occlusion
  • Drug-coated balloons
  • Drug-coated stents
  • Endovascular revascularization
  • Peripheral artery disease
  • Superficial femoral artery

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{5d94b759c88940bfa3338bca0860555c,
title = "Drug-Coated Balloon and Stent Therapies for Endovascular Treatment of Atherosclerotic Superficial Femoral Artery Disease",
abstract = "Endovascular management of superficial femoral artery disease has historically been limited to percutaneous balloon angioplasty, atherectomy, and bare-metal stents. However, these therapies have been plagued by high restenosis and target lesion revascularization rates. More recent technologies such as drug-coated stents and balloons are designed to combat restenosis by locally delivering antiproliferative drugs. Several randomized controlled trials have directly compared these antiproliferative drug-delivering devices to their non-drug-coated counterparts. Additionally, trials are currently ongoing to compare use of drug-coated technologies in combination with traditional therapies in hope of synergistic effects. This review gathers data from currently published clinical trials, provides an overview of upcoming clinical studies utilizing drug-coated technology, and explores the possible impact these devices may have on clinical practice.",
keywords = "Chronic total occlusion, Drug-coated balloons, Drug-coated stents, Endovascular revascularization, Peripheral artery disease, Superficial femoral artery",
author = "Subhash Banerjee and Karan Sarode and Atif Mohammad and Brilakis, {Emmanouil S.}",
year = "2015",
month = "5",
day = "1",
doi = "10.1007/s11886-015-0586-8",
language = "English (US)",
volume = "17",
journal = "Current Cardiology Reports",
issn = "1523-3782",
publisher = "Current Medicine Group",
number = "5",

}

TY - JOUR

T1 - Drug-Coated Balloon and Stent Therapies for Endovascular Treatment of Atherosclerotic Superficial Femoral Artery Disease

AU - Banerjee, Subhash

AU - Sarode, Karan

AU - Mohammad, Atif

AU - Brilakis, Emmanouil S.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Endovascular management of superficial femoral artery disease has historically been limited to percutaneous balloon angioplasty, atherectomy, and bare-metal stents. However, these therapies have been plagued by high restenosis and target lesion revascularization rates. More recent technologies such as drug-coated stents and balloons are designed to combat restenosis by locally delivering antiproliferative drugs. Several randomized controlled trials have directly compared these antiproliferative drug-delivering devices to their non-drug-coated counterparts. Additionally, trials are currently ongoing to compare use of drug-coated technologies in combination with traditional therapies in hope of synergistic effects. This review gathers data from currently published clinical trials, provides an overview of upcoming clinical studies utilizing drug-coated technology, and explores the possible impact these devices may have on clinical practice.

AB - Endovascular management of superficial femoral artery disease has historically been limited to percutaneous balloon angioplasty, atherectomy, and bare-metal stents. However, these therapies have been plagued by high restenosis and target lesion revascularization rates. More recent technologies such as drug-coated stents and balloons are designed to combat restenosis by locally delivering antiproliferative drugs. Several randomized controlled trials have directly compared these antiproliferative drug-delivering devices to their non-drug-coated counterparts. Additionally, trials are currently ongoing to compare use of drug-coated technologies in combination with traditional therapies in hope of synergistic effects. This review gathers data from currently published clinical trials, provides an overview of upcoming clinical studies utilizing drug-coated technology, and explores the possible impact these devices may have on clinical practice.

KW - Chronic total occlusion

KW - Drug-coated balloons

KW - Drug-coated stents

KW - Endovascular revascularization

KW - Peripheral artery disease

KW - Superficial femoral artery

UR - http://www.scopus.com/inward/record.url?scp=84928626959&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928626959&partnerID=8YFLogxK

U2 - 10.1007/s11886-015-0586-8

DO - 10.1007/s11886-015-0586-8

M3 - Article

C2 - 25894799

AN - SCOPUS:84928626959

VL - 17

JO - Current Cardiology Reports

JF - Current Cardiology Reports

SN - 1523-3782

IS - 5

ER -