Drug discovery targeting heme-based sensors and their coupled activities

Eduardo Henrique Silva Sousa, Luiz Gonzaga de França Lopes, Gonzalo Gonzalez, Marie Alda Gilles-Gonzalez

Research output: Contribution to journalShort survey

6 Citations (Scopus)

Abstract

Heme-based sensors have emerged during the last 20 years as being a large family of proteins that occur in all kingdoms of life. A myriad of biological adaptations are associated with these sensors, which include vasodilation, bacterial virulence, dormancy, chemotaxis, biofilm formation, among others. Due to the key activities regulated by these proteins along with many other systems that use similar output domains, there is a growing interest in developing small molecules as their regulators. Here, we review the development of potential activators and inhibitors for many of these systems, including human soluble guanylate cyclase, c-di-GMP-related enzymes, Mycobacterium tuberculosis DevR/DevS/DosT (differentially expressed in virulent strain response regulator/sensor/dormancy survival sensor T), the Rev-erb-α and β nuclear receptor, among others. The possible roles of these molecules as biochemical tools, therapeutic agents, and novel antibiotics are critically examined.

Original languageEnglish (US)
Pages (from-to)12-20
Number of pages9
JournalJournal of Inorganic Biochemistry
Volume167
DOIs
StatePublished - Feb 1 2017

Fingerprint

Drug Discovery
Drug Delivery Systems
Heme
Biological Adaptation
Sensors
Chemotaxis
Biofilms
Cytoplasmic and Nuclear Receptors
Mycobacterium tuberculosis
Vasodilation
Virulence
Proteins
Anti-Bacterial Agents
Molecules
Survival
Guanylate Cyclase
Enzymes
Therapeutics
Soluble Guanylyl Cyclase
bis(3',5')-cyclic diguanylic acid

Keywords

  • Drug discovery
  • Heme-based sensor
  • Histidine protein kinase
  • Nuclear receptor
  • Nucleotide cyclase
  • Phosphodiesterase

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Cite this

Drug discovery targeting heme-based sensors and their coupled activities. / Sousa, Eduardo Henrique Silva; Lopes, Luiz Gonzaga de França; Gonzalez, Gonzalo; Gilles-Gonzalez, Marie Alda.

In: Journal of Inorganic Biochemistry, Vol. 167, 01.02.2017, p. 12-20.

Research output: Contribution to journalShort survey

Sousa, Eduardo Henrique Silva ; Lopes, Luiz Gonzaga de França ; Gonzalez, Gonzalo ; Gilles-Gonzalez, Marie Alda. / Drug discovery targeting heme-based sensors and their coupled activities. In: Journal of Inorganic Biochemistry. 2017 ; Vol. 167. pp. 12-20.
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