Drug-induced acute liver failure

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Although acute liver failure caused by drug-induced liver injury comprises a small fraction of overall drug-induced liver injury, these patients require high resource use and have relatively poor outcomes. Drug-induced liver injury caused by idiosyncrasy more often leads to death or transplantation than does acetaminophen acute liver failure, but the number of patients in each category receiving a graft is roughly the same. Efforts in the future to improve outcomes should focus on more effective treatments and better methods to identify those that might experience poor outcomes.

Original languageEnglish (US)
Pages (from-to)575-586
Number of pages12
JournalClinics in Liver Disease
Volume17
Issue number4
DOIs
StatePublished - Nov 2013

Fingerprint

Chemical and Drug Induced Liver Injury
Acute Liver Failure
Pharmaceutical Preparations
Acetaminophen
Transplantation
Transplants
Therapeutics

Keywords

  • Coagulopathy
  • Encephalopathy
  • Hepatocyte injury
  • Liver transplantation

ASJC Scopus subject areas

  • Hepatology

Cite this

Drug-induced acute liver failure. / Lee, William M.

In: Clinics in Liver Disease, Vol. 17, No. 4, 11.2013, p. 575-586.

Research output: Contribution to journalArticle

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