TY - JOUR
T1 - Drug-induced hepatotoxicity
AU - Lee, W. M.
PY - 1995/10/26
Y1 - 1995/10/26
N2 - Drug-induced liver injury is a potential complication of nearly every medication that is prescribed, because the liver is central to the metabolic disposition of virtually all drugs and foreign substances.1–3 Although drugs are usually metabolized without injury to the liver, many fatal and near-fatal drug reactions occur each year. A few compounds produce metabolites that cause liver injury in a uniform, dose-dependent fashion.4–6 Most agents form a toxic byproduct only in rare persons. Injury to hepatocytes results either directly from the disruption of intracellular function or membrane integrity or indirectly from immune-mediated membrane damage. Factors promoting the accumulation.
AB - Drug-induced liver injury is a potential complication of nearly every medication that is prescribed, because the liver is central to the metabolic disposition of virtually all drugs and foreign substances.1–3 Although drugs are usually metabolized without injury to the liver, many fatal and near-fatal drug reactions occur each year. A few compounds produce metabolites that cause liver injury in a uniform, dose-dependent fashion.4–6 Most agents form a toxic byproduct only in rare persons. Injury to hepatocytes results either directly from the disruption of intracellular function or membrane integrity or indirectly from immune-mediated membrane damage. Factors promoting the accumulation.
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U2 - 10.1056/NEJM199510263331706
DO - 10.1056/NEJM199510263331706
M3 - Review article
C2 - 7565951
AN - SCOPUS:0028817867
SN - 0028-4793
VL - 333
SP - 1118
EP - 1127
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 17
ER -