TY - JOUR
T1 - Drug-Induced Liver Injury Associated with HIV Medications
AU - Jain, Mamta K.
PY - 2007/8
Y1 - 2007/8
N2 - Antiretroviral therapy (ART) for HIV infection frequently has been associated with elevated liver enzyme levels. Determining the cause of elevated liver enzyme levels in patients who have HIV is difficult because ART usually consists of three different drugs, patients may be taking additional hepatotoxic medications and patients who have HIV often suffer from other liver diseases. Several agents, however, are recognized as having noteworthy and specific patterns of toxicity. This article reviews the different HIV drug classes, incidence of elevated liver enzyme values by class and by individual drug, risk factors, specific toxicities, and possible mechanisms of injury.
AB - Antiretroviral therapy (ART) for HIV infection frequently has been associated with elevated liver enzyme levels. Determining the cause of elevated liver enzyme levels in patients who have HIV is difficult because ART usually consists of three different drugs, patients may be taking additional hepatotoxic medications and patients who have HIV often suffer from other liver diseases. Several agents, however, are recognized as having noteworthy and specific patterns of toxicity. This article reviews the different HIV drug classes, incidence of elevated liver enzyme values by class and by individual drug, risk factors, specific toxicities, and possible mechanisms of injury.
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U2 - 10.1016/j.cld.2007.06.008
DO - 10.1016/j.cld.2007.06.008
M3 - Review article
C2 - 17723923
AN - SCOPUS:34548122764
SN - 1089-3261
VL - 11
SP - 615
EP - 639
JO - Clinics in Liver Disease
JF - Clinics in Liver Disease
IS - 3
ER -