Years ago, the practice of medicine required much artful prescribing of multiple ingredients to be skillfully compounded specifically for individual patients. At least one ingredient was generally selected to attack each symptom. The phenomenon of synergism was often discussed and sought. Antagonism was recognized in the form of “antidotes,” and some ingredients were added solely to control an undesired action while retaining the beneficial effect of other drugs. But there was no real understanding of how drugs interacted. Today, more of our drugs attack disease by way of its etiology or the basic mechanism of its pathophysiology, so that it.
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