Drug loaded multilayered gold nanorods for combined photothermal and chemotherapy

Haiyan Chen; Xuemei Chi; Bowen Li; Min Zhang; Yuxiang Ma; Samuel Achilefu; Yueqing Gu

doi:10.1039/c3bm60323g

Drug loaded multilayered gold nanorods for combined photothermal and chemotherapy

Haiyan Chen, Xuemei Chi, Bowen Li, Min Zhang, Yuxiang Ma, Samuel Achilefu, Yueqing Gu

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

In this study, gold nanorods (AuNRs) were first stabilized by hexadecyltrimethylammonium bromide (CTAB) and then coated with two kinds of polyelectrolytes (PE) and BSA to obtain multi-layered AuNRs (AuNRs-PE-BSA). Furthermore, the anti-cancer drug doxorubicin (DOX) was encapsulated into AuNRs-PE-BSA by the electrostatic force and the nanocomposites formed were named AuNRs/DOX-PE-BSA. The success of coating was verified by transmission electron microscopy (TEM), zeta potential, gel-electrophoresis and thermogravimetric analysis (TGA). The MTT assay indicated that the cytotoxicity of AuNRs decreased dramatically after multi-layer capping. The time-dependent nucleus-targeting capability of AuNRs/DOX-PE-BSA was confirmed in cell affinity evaluations. The in vitro and in vivo experiments demonstrated that AuNRs/DOX-PE-BSA, which combined photothermal and chemotherapy for tumor therapy, bears a markedly improved curative effect and holds promising prospects in the field of nanomedicine.

Original language	English (US)
Pages (from-to)	996-1006
Number of pages	11
Journal	Biomaterials Science
Volume	2
Issue number	7
DOIs	https://doi.org/10.1039/c3bm60323g
State	Published - Jul 2014
Externally published	Yes

ASJC Scopus subject areas

Biomedical Engineering
General Materials Science

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title = "Drug loaded multilayered gold nanorods for combined photothermal and chemotherapy",

abstract = "In this study, gold nanorods (AuNRs) were first stabilized by hexadecyltrimethylammonium bromide (CTAB) and then coated with two kinds of polyelectrolytes (PE) and BSA to obtain multi-layered AuNRs (AuNRs-PE-BSA). Furthermore, the anti-cancer drug doxorubicin (DOX) was encapsulated into AuNRs-PE-BSA by the electrostatic force and the nanocomposites formed were named AuNRs/DOX-PE-BSA. The success of coating was verified by transmission electron microscopy (TEM), zeta potential, gel-electrophoresis and thermogravimetric analysis (TGA). The MTT assay indicated that the cytotoxicity of AuNRs decreased dramatically after multi-layer capping. The time-dependent nucleus-targeting capability of AuNRs/DOX-PE-BSA was confirmed in cell affinity evaluations. The in vitro and in vivo experiments demonstrated that AuNRs/DOX-PE-BSA, which combined photothermal and chemotherapy for tumor therapy, bears a markedly improved curative effect and holds promising prospects in the field of nanomedicine.",

author = "Haiyan Chen and Xuemei Chi and Bowen Li and Min Zhang and Yuxiang Ma and Samuel Achilefu and Yueqing Gu",

year = "2014",

month = jul,

doi = "10.1039/c3bm60323g",

language = "English (US)",

volume = "2",

pages = "996--1006",

journal = "Biomaterials Science",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Drug loaded multilayered gold nanorods for combined photothermal and chemotherapy

AU - Chen, Haiyan

AU - Chi, Xuemei

AU - Li, Bowen

AU - Zhang, Min

AU - Ma, Yuxiang

AU - Achilefu, Samuel

AU - Gu, Yueqing

PY - 2014/7

Y1 - 2014/7

N2 - In this study, gold nanorods (AuNRs) were first stabilized by hexadecyltrimethylammonium bromide (CTAB) and then coated with two kinds of polyelectrolytes (PE) and BSA to obtain multi-layered AuNRs (AuNRs-PE-BSA). Furthermore, the anti-cancer drug doxorubicin (DOX) was encapsulated into AuNRs-PE-BSA by the electrostatic force and the nanocomposites formed were named AuNRs/DOX-PE-BSA. The success of coating was verified by transmission electron microscopy (TEM), zeta potential, gel-electrophoresis and thermogravimetric analysis (TGA). The MTT assay indicated that the cytotoxicity of AuNRs decreased dramatically after multi-layer capping. The time-dependent nucleus-targeting capability of AuNRs/DOX-PE-BSA was confirmed in cell affinity evaluations. The in vitro and in vivo experiments demonstrated that AuNRs/DOX-PE-BSA, which combined photothermal and chemotherapy for tumor therapy, bears a markedly improved curative effect and holds promising prospects in the field of nanomedicine.

AB - In this study, gold nanorods (AuNRs) were first stabilized by hexadecyltrimethylammonium bromide (CTAB) and then coated with two kinds of polyelectrolytes (PE) and BSA to obtain multi-layered AuNRs (AuNRs-PE-BSA). Furthermore, the anti-cancer drug doxorubicin (DOX) was encapsulated into AuNRs-PE-BSA by the electrostatic force and the nanocomposites formed were named AuNRs/DOX-PE-BSA. The success of coating was verified by transmission electron microscopy (TEM), zeta potential, gel-electrophoresis and thermogravimetric analysis (TGA). The MTT assay indicated that the cytotoxicity of AuNRs decreased dramatically after multi-layer capping. The time-dependent nucleus-targeting capability of AuNRs/DOX-PE-BSA was confirmed in cell affinity evaluations. The in vitro and in vivo experiments demonstrated that AuNRs/DOX-PE-BSA, which combined photothermal and chemotherapy for tumor therapy, bears a markedly improved curative effect and holds promising prospects in the field of nanomedicine.

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JO - Biomaterials Science

JF - Biomaterials Science

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Drug loaded multilayered gold nanorods for combined photothermal and chemotherapy

Abstract

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