Drug-resistant brain metastases: A role for pharmacology, tumor evolution, and too-late therapy

Thomas Stricker, Carlos L. Arteaga

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Two recent studies report deep molecular profiling of matched brain metastases and primary tumors. In both studies, somatic alterations in the brain metastases were frequently discordant with those in the primary tumor, suggesting divergent evolution at metastatic sites and raising questions about the use of biomarkers in patients in clinical trials with targeted therapies.

Original languageEnglish (US)
Pages (from-to)1124-1126
Number of pages3
JournalCancer Discovery
Volume5
Issue number11
DOIs
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Oncology

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