D2-Family receptor distribution in human postmortem tissue: An autoradiographic study

R. A. Lahti, R. C. Roberts, C. A. Tamminga

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Abstract

The distribution throughout the normal human brain of the dopamine D2-family of receptors were investigated autoradiographically. Three ligands were used, [3H]-YM-09151-2 to define the D2, D3, D4 receptors; [3H]raclopride the D2 D3 receptors; and [3H](+)-7-OH-DPAT, in the presence of GTP, demonstrates D3 distribution. [3H]YM-09151-2 and [3H]raclopride binding were highest in caudate (121 vs 130 fmol mg-1), putamen (96 vs 136 fmol mg-1), and nucleus accumbens (113 vs 120 fmol mg-1). [3H]YM-09151-2 also displayed significant binding in several cortical areas (56-39 fmol mg-1) and hippocampus (27 fmol mg-1). [3H](+)-7-OH-DPAT was highest in the nucleus accumbens. Based upon the ligands properties it is inferred that D2 distribution is highest in putamen, caudate and nucleus accumbens; D3 in the nucleus accumbens; D4 receptor in cortical areas and hippocampus.

Original languageEnglish (US)
Pages (from-to)2505-2512
Number of pages8
JournalNeuroReport
Volume6
Issue number18
Publication statusPublished - 1995

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Keywords

  • [H](+)-7-Hydroxy-DPAT
  • [H]raclopride
  • [H]YM-09151-2
  • D2
  • D3
  • D4
  • Dopamine
  • Dopamine receptors
  • Human
  • Postmortem

ASJC Scopus subject areas

  • Neuroscience(all)

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