The distribution throughout the normal human brain of the dopamine D2-family of receptors were investigated autoradiographically. Three ligands were used, [3H]-YM-09151-2 to define the D2, D3, D4 receptors; [3H]raclopride the D2 D3 receptors; and [3H](+)-7-OH-DPAT, in the presence of GTP, demonstrates D3 distribution. [3H]YM-09151-2 and [3H]raclopride binding were highest in caudate (121 vs 130 fmol mg"1), putamen (96 vs 136 fmol mg"1), and nucleus accumbens (113 vs 120 fmol mg_1). [3H]YM-09151-2 also displayed significant binding in several cortical areas (56-39 fmol mg"1) and hippocampus (27 fmol mg"1). [3H](+)-7-OH-DPAT was highest in the nucleus accumbens. Based upon the ligands properties it is inferred that D2 distribution is highest in putamen, caudate and nucleus accumbens; D3 in the nucleus accumbens; D4 receptor in cortical areas and hippocampus.
- Dopamine receptors
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