D2-family receptor distribution in human postmortem tissue: An autoradiographic study

R. A. Lahti; R. C. Roberts; C. A. Tamminga

doi:10.1097/00001756-199512150-00015

D2-family receptor distribution in human postmortem tissue: An autoradiographic study

R. A. Lahti, R. C. Roberts, C. A. Tamminga

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

The distribution throughout the normal human brain of the dopamine D2-family of receptors were investigated autoradiographically. Three ligands were used, [3H]-YM-09151-2 to define the D2, D3, D4 receptors; [3H]raclopride the D2 D3 receptors; and [3H](+)-7-OH-DPAT, in the presence of GTP, demonstrates D3 distribution. [3H]YM-09151-2 and [3H]raclopride binding were highest in caudate (121 vs 130 fmol mg"1), putamen (96 vs 136 fmol mg"1), and nucleus accumbens (113 vs 120 fmol mg_1). [3H]YM-09151-2 also displayed significant binding in several cortical areas (56-39 fmol mg"1) and hippocampus (27 fmol mg"1). [3H](+)-7-OH-DPAT was highest in the nucleus accumbens. Based upon the ligands properties it is inferred that D2 distribution is highest in putamen, caudate and nucleus accumbens; D3 in the nucleus accumbens; D4 receptor in cortical areas and hippocampus.

Original language	English (US)
Pages (from-to)	2505-2512
Number of pages	8
Journal	NeuroReport
Volume	6
Issue number	18
DOIs	https://doi.org/10.1097/00001756-199512150-00015
State	Published - Dec 1995

Keywords

D2
D3
D4
Dopamine
Dopamine receptors
Human
Postmortem
[H](+)-7-hydroxy-DPAT
[H]raclopride
[H]ym-09151-2

ASJC Scopus subject areas

General Neuroscience

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10.1097/00001756-199512150-00015

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title = "D2-family receptor distribution in human postmortem tissue: An autoradiographic study",

abstract = "The distribution throughout the normal human brain of the dopamine D2-family of receptors were investigated autoradiographically. Three ligands were used, [3H]-YM-09151-2 to define the D2, D3, D4 receptors; [3H]raclopride the D2 D3 receptors; and [3H](+)-7-OH-DPAT, in the presence of GTP, demonstrates D3 distribution. [3H]YM-09151-2 and [3H]raclopride binding were highest in caudate (121 vs 130 fmol mg{"}1), putamen (96 vs 136 fmol mg{"}1), and nucleus accumbens (113 vs 120 fmol mg_1). [3H]YM-09151-2 also displayed significant binding in several cortical areas (56-39 fmol mg{"}1) and hippocampus (27 fmol mg{"}1). [3H](+)-7-OH-DPAT was highest in the nucleus accumbens. Based upon the ligands properties it is inferred that D2 distribution is highest in putamen, caudate and nucleus accumbens; D3 in the nucleus accumbens; D4 receptor in cortical areas and hippocampus.",

keywords = "D2, D3, D4, Dopamine, Dopamine receptors, Human, Postmortem, [H](+)-7-hydroxy-DPAT, [H]raclopride, [H]ym-09151-2",

author = "Lahti, {R. A.} and Roberts, {R. C.} and Tamminga, {C. A.}",

year = "1995",

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doi = "10.1097/00001756-199512150-00015",

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AU - Roberts, R. C.

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AB - The distribution throughout the normal human brain of the dopamine D2-family of receptors were investigated autoradiographically. Three ligands were used, [3H]-YM-09151-2 to define the D2, D3, D4 receptors; [3H]raclopride the D2 D3 receptors; and [3H](+)-7-OH-DPAT, in the presence of GTP, demonstrates D3 distribution. [3H]YM-09151-2 and [3H]raclopride binding were highest in caudate (121 vs 130 fmol mg"1), putamen (96 vs 136 fmol mg"1), and nucleus accumbens (113 vs 120 fmol mg_1). [3H]YM-09151-2 also displayed significant binding in several cortical areas (56-39 fmol mg"1) and hippocampus (27 fmol mg"1). [3H](+)-7-OH-DPAT was highest in the nucleus accumbens. Based upon the ligands properties it is inferred that D2 distribution is highest in putamen, caudate and nucleus accumbens; D3 in the nucleus accumbens; D4 receptor in cortical areas and hippocampus.

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KW - Dopamine receptors

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D2-family receptor distribution in human postmortem tissue: An autoradiographic study

Abstract

Keywords

ASJC Scopus subject areas

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