Dual defect in metabolism of very-low-density lipoprotein triglycerides. Patients with type 5 hyperlipoproteinemia

Y. A. Kesaniemi, Scott M Grundy

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Abstract

Transport of very-low-density lipoprotein (VLDL) triglycerides (TGs) were studied in eight patients with type 5 hyperlipoproteinemia (HLP). Results were compared to those from patients with type 4 HLP. Type 4 patients had either overproduction of VLDL TGs (nine patients) or defective clearance of VLDL TGs (eight patients). Patients with type 5 HLP were found to have increased production rates of VLDL TG, but also reduced fractional catabolic rates of VLDL TGs. Synthesis rates of VLDL TGs in type 5 were similar to those in type 4 patients with overproduction of VLDL TGs. The mean fractional catabolic rate in patients with type 5 HLP also were similar to those of type 4 patients with defective clearance. This study demonstrates that in most patients with type 5 HLP there is a dual defect in TG metabolism-overproduction of VLDL TGs and a clearance defect for TG-rich lipoproteins.

Original languageEnglish (US)
Pages (from-to)2542-2547
Number of pages6
JournalJournal of the American Medical Association
Volume251
Issue number19
DOIs
StatePublished - 1984

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Hyperlipoproteinemia Type V
Triglycerides
Hyperlipoproteinemia Type IV
very low density lipoprotein triglyceride
Lipoprotein(a)
Lipoproteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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