Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3-CA1 synapses

V. Y. Bolshakov, L. Carboni, M. H. Cobb, S. A. Siegelbaum, F. Belardetti

Research output: Contribution to journalArticle

180 Citations (Scopus)

Abstract

Although the function of the p42/p44 mitogen-activated protein (MAP) kinase pathway in long-term potentiation at hippocampal CA3-CA1 synapses has been well described, relatively little is known about the importance of the p38 MAP kinase pathway in synaptic plasticity. Here we show that the p38 MAP kinase pathway, a parallel signaling cascade activated by distinct upstream kinases, mediates the induction of metabotropic glutamate receptor-dependent long-term depression at CA3-CA1 synapses. Thus, two parallel MAP kinase pathways contribute to opposing forms of long-term plasticity at a central synapse.

Original languageEnglish (US)
Pages (from-to)1107-1112
Number of pages6
JournalNature Neuroscience
Volume3
Issue number11
DOIs
StatePublished - 2000

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Mitogen-Activated Protein Kinases
Synapses
p38 Mitogen-Activated Protein Kinases
Metabotropic Glutamate Receptors
Neuronal Plasticity
Long-Term Potentiation
Mitogen-Activated Protein Kinase 1
Phosphotransferases

ASJC Scopus subject areas

  • Neuroscience(all)

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Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3-CA1 synapses. / Bolshakov, V. Y.; Carboni, L.; Cobb, M. H.; Siegelbaum, S. A.; Belardetti, F.

In: Nature Neuroscience, Vol. 3, No. 11, 2000, p. 1107-1112.

Research output: Contribution to journalArticle

Bolshakov, VY, Carboni, L, Cobb, MH, Siegelbaum, SA & Belardetti, F 2000, 'Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3-CA1 synapses', Nature Neuroscience, vol. 3, no. 11, pp. 1107-1112. https://doi.org/10.1038/80624
Bolshakov, V. Y. ; Carboni, L. ; Cobb, M. H. ; Siegelbaum, S. A. ; Belardetti, F. / Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3-CA1 synapses. In: Nature Neuroscience. 2000 ; Vol. 3, No. 11. pp. 1107-1112.
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