Duplication and divergence in humans and chimpanzees

Stephen Wooding, Lynn B. Jorde

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

It has become a truism that we humans are genetically about 99% identical to chimpanzees. The origins of this assertion are clear: among early studies of DNA sequences, nucleotide identity between humans and chimpanzees was found to average around 98.9%. However, this figure is correct only with respect to regions of the genome that are shared between humans and chimpanzees. Often ignored are the many parts of their genomes that are not shared. Genomic rearrangements, including insertions, deletions, translocations and duplications, have long been recognized as potentially important sources of novel genomic material and are known to account for major genomic differences between humans and chimpanzees. Further, such changes have been implicated in a number of genetic disorders, such as DiGeorge, Angelman/Prader-Willi and Charcot-Marie-Tooth syndromes.

Original languageEnglish (US)
Pages (from-to)335-338
Number of pages4
JournalBioEssays
Volume28
Issue number4
DOIs
StatePublished - Apr 2006

Fingerprint

Pan troglodytes
Genes
DNA sequences
genomics
Nucleotides
Genome
Charcot-Marie-Tooth Disease
Inborn Genetic Diseases
genome
genetic disorders
teeth
nucleotides
nucleotide sequences

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Biochemistry
  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

Cite this

Duplication and divergence in humans and chimpanzees. / Wooding, Stephen; Jorde, Lynn B.

In: BioEssays, Vol. 28, No. 4, 04.2006, p. 335-338.

Research output: Contribution to journalArticle

Wooding, S & Jorde, LB 2006, 'Duplication and divergence in humans and chimpanzees', BioEssays, vol. 28, no. 4, pp. 335-338. https://doi.org/10.1002/bies.20385
Wooding, Stephen ; Jorde, Lynn B. / Duplication and divergence in humans and chimpanzees. In: BioEssays. 2006 ; Vol. 28, No. 4. pp. 335-338.
@article{00ddd77f51db46de95db6860518d98e8,
title = "Duplication and divergence in humans and chimpanzees",
abstract = "It has become a truism that we humans are genetically about 99{\%} identical to chimpanzees. The origins of this assertion are clear: among early studies of DNA sequences, nucleotide identity between humans and chimpanzees was found to average around 98.9{\%}. However, this figure is correct only with respect to regions of the genome that are shared between humans and chimpanzees. Often ignored are the many parts of their genomes that are not shared. Genomic rearrangements, including insertions, deletions, translocations and duplications, have long been recognized as potentially important sources of novel genomic material and are known to account for major genomic differences between humans and chimpanzees. Further, such changes have been implicated in a number of genetic disorders, such as DiGeorge, Angelman/Prader-Willi and Charcot-Marie-Tooth syndromes.",
author = "Stephen Wooding and Jorde, {Lynn B.}",
year = "2006",
month = "4",
doi = "10.1002/bies.20385",
language = "English (US)",
volume = "28",
pages = "335--338",
journal = "BioEssays",
issn = "0265-9247",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - Duplication and divergence in humans and chimpanzees

AU - Wooding, Stephen

AU - Jorde, Lynn B.

PY - 2006/4

Y1 - 2006/4

N2 - It has become a truism that we humans are genetically about 99% identical to chimpanzees. The origins of this assertion are clear: among early studies of DNA sequences, nucleotide identity between humans and chimpanzees was found to average around 98.9%. However, this figure is correct only with respect to regions of the genome that are shared between humans and chimpanzees. Often ignored are the many parts of their genomes that are not shared. Genomic rearrangements, including insertions, deletions, translocations and duplications, have long been recognized as potentially important sources of novel genomic material and are known to account for major genomic differences between humans and chimpanzees. Further, such changes have been implicated in a number of genetic disorders, such as DiGeorge, Angelman/Prader-Willi and Charcot-Marie-Tooth syndromes.

AB - It has become a truism that we humans are genetically about 99% identical to chimpanzees. The origins of this assertion are clear: among early studies of DNA sequences, nucleotide identity between humans and chimpanzees was found to average around 98.9%. However, this figure is correct only with respect to regions of the genome that are shared between humans and chimpanzees. Often ignored are the many parts of their genomes that are not shared. Genomic rearrangements, including insertions, deletions, translocations and duplications, have long been recognized as potentially important sources of novel genomic material and are known to account for major genomic differences between humans and chimpanzees. Further, such changes have been implicated in a number of genetic disorders, such as DiGeorge, Angelman/Prader-Willi and Charcot-Marie-Tooth syndromes.

UR - http://www.scopus.com/inward/record.url?scp=33645808692&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645808692&partnerID=8YFLogxK

U2 - 10.1002/bies.20385

DO - 10.1002/bies.20385

M3 - Article

C2 - 16547951

AN - SCOPUS:33645808692

VL - 28

SP - 335

EP - 338

JO - BioEssays

JF - BioEssays

SN - 0265-9247

IS - 4

ER -