Dying for NF-κB? Control of cell death by transcriptional regulation of the apoptotic machinery

Ezra Burstein, Colin S. Duckett

Research output: Contribution to journalReview article

106 Scopus citations

Abstract

The transcription factor nuclear factor κB (NF-κB) is a pleiotropic protein complex that is activated from a sequestered, cytoplasmic form by pro-inflammatory extracellular signals and cellular stress. Several hundred cellular genes have been shown to be regulated by NF-κB, including cytokines, chemokines and adhesion molecules. Nearly eight years ago, a flurry of publications showed that loss or suppression of NF-κB results in an enhanced sensitivity to apoptosis. In the ensuing years, activation of NF-κB has become almost synonymous with enhanced cell survival, although more recent data suggests that this transcription factor plays a more complex role in the regulation of cell death.

Original languageEnglish (US)
Pages (from-to)732-737
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume15
Issue number6
DOIs
StatePublished - Dec 2003

ASJC Scopus subject areas

  • Cell Biology

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