Dynamic breast tumor oximetry: The development of prognostic radiology

Yulin Song, Anca Constantinescu, Ralph P. Mason

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A novel pre clinical approach to evaluating tumor oxygen dynamics was recently introduced (Am. J. Clin. Oncol. 24, 462-466 (2001)). FREDOM (Fluorocarbon Relaxometry using Echo planar imaging for Dynamic Oxygen Mapping) allows maps of tumor pO2 including 50-150 individual locations simultaneously to be produced with typical in plane resolution of 1.25 mm in 6.5 mins. The technique has been applied extensively in rat prostate tumors and is now demonstrated in the rat breast 13762NF adenocarcinoma. When anesthetized rats breathed 33% oxygen, mean baseline pO2 was in the range 17 ± 2 (se) torr to 74 ± 4 torr with mean value for nine tumors 46 ± 8 torr. However, small tumors (< 2.2 cm3) were significantly better oxygenated with mean pO2 = 63 ± 7 torr than large tumors (> 2.4 cm3) with mean pO2 24 ± 5 torr (p< 0.002). Switching the inhaled gas to oxygen or carbogen produced a significant and rapid increase in mean pO2 for both small and larger tumors (p< 0.05). Given the increasing evidence that tumor oxygenation is related to therapeutic outcome, we believe this approach to measuring tumor oxygen dynamics can be of value in predicting response to therapy, evaluating adjuvant interventions designed to modulate response to therapy, and in providing "Prognostic Radiology".

Original languageEnglish (US)
Pages (from-to)471-478
Number of pages8
JournalTechnology in Cancer Research and Treatment
Volume1
Issue number6
StatePublished - Dec 2002

Fingerprint

Oximetry
Radiology
Breast Neoplasms
Oxygen
Neoplasms
Echo-Planar Imaging
Fluorocarbons
Prostate
Adenocarcinoma
Breast
Therapeutics
Gases

Keywords

  • Breast tumor
  • Carbogen
  • Hexafluorobenzene
  • Hypoxia
  • Magnetic resonance imaging
  • Oxygen

ASJC Scopus subject areas

  • Cancer Research
  • Radiology Nuclear Medicine and imaging

Cite this

Dynamic breast tumor oximetry : The development of prognostic radiology. / Song, Yulin; Constantinescu, Anca; Mason, Ralph P.

In: Technology in Cancer Research and Treatment, Vol. 1, No. 6, 12.2002, p. 471-478.

Research output: Contribution to journalArticle

@article{e384d2c29c1e42be9dc2310ccb1854d6,
title = "Dynamic breast tumor oximetry: The development of prognostic radiology",
abstract = "A novel pre clinical approach to evaluating tumor oxygen dynamics was recently introduced (Am. J. Clin. Oncol. 24, 462-466 (2001)). FREDOM (Fluorocarbon Relaxometry using Echo planar imaging for Dynamic Oxygen Mapping) allows maps of tumor pO2 including 50-150 individual locations simultaneously to be produced with typical in plane resolution of 1.25 mm in 6.5 mins. The technique has been applied extensively in rat prostate tumors and is now demonstrated in the rat breast 13762NF adenocarcinoma. When anesthetized rats breathed 33{\%} oxygen, mean baseline pO2 was in the range 17 ± 2 (se) torr to 74 ± 4 torr with mean value for nine tumors 46 ± 8 torr. However, small tumors (< 2.2 cm3) were significantly better oxygenated with mean pO2 = 63 ± 7 torr than large tumors (> 2.4 cm3) with mean pO2 24 ± 5 torr (p< 0.002). Switching the inhaled gas to oxygen or carbogen produced a significant and rapid increase in mean pO2 for both small and larger tumors (p< 0.05). Given the increasing evidence that tumor oxygenation is related to therapeutic outcome, we believe this approach to measuring tumor oxygen dynamics can be of value in predicting response to therapy, evaluating adjuvant interventions designed to modulate response to therapy, and in providing {"}Prognostic Radiology{"}.",
keywords = "Breast tumor, Carbogen, Hexafluorobenzene, Hypoxia, Magnetic resonance imaging, Oxygen",
author = "Yulin Song and Anca Constantinescu and Mason, {Ralph P.}",
year = "2002",
month = "12",
language = "English (US)",
volume = "1",
pages = "471--478",
journal = "Technology in Cancer Research and Treatment",
issn = "1533-0346",
publisher = "Adenine Press",
number = "6",

}

TY - JOUR

T1 - Dynamic breast tumor oximetry

T2 - The development of prognostic radiology

AU - Song, Yulin

AU - Constantinescu, Anca

AU - Mason, Ralph P.

PY - 2002/12

Y1 - 2002/12

N2 - A novel pre clinical approach to evaluating tumor oxygen dynamics was recently introduced (Am. J. Clin. Oncol. 24, 462-466 (2001)). FREDOM (Fluorocarbon Relaxometry using Echo planar imaging for Dynamic Oxygen Mapping) allows maps of tumor pO2 including 50-150 individual locations simultaneously to be produced with typical in plane resolution of 1.25 mm in 6.5 mins. The technique has been applied extensively in rat prostate tumors and is now demonstrated in the rat breast 13762NF adenocarcinoma. When anesthetized rats breathed 33% oxygen, mean baseline pO2 was in the range 17 ± 2 (se) torr to 74 ± 4 torr with mean value for nine tumors 46 ± 8 torr. However, small tumors (< 2.2 cm3) were significantly better oxygenated with mean pO2 = 63 ± 7 torr than large tumors (> 2.4 cm3) with mean pO2 24 ± 5 torr (p< 0.002). Switching the inhaled gas to oxygen or carbogen produced a significant and rapid increase in mean pO2 for both small and larger tumors (p< 0.05). Given the increasing evidence that tumor oxygenation is related to therapeutic outcome, we believe this approach to measuring tumor oxygen dynamics can be of value in predicting response to therapy, evaluating adjuvant interventions designed to modulate response to therapy, and in providing "Prognostic Radiology".

AB - A novel pre clinical approach to evaluating tumor oxygen dynamics was recently introduced (Am. J. Clin. Oncol. 24, 462-466 (2001)). FREDOM (Fluorocarbon Relaxometry using Echo planar imaging for Dynamic Oxygen Mapping) allows maps of tumor pO2 including 50-150 individual locations simultaneously to be produced with typical in plane resolution of 1.25 mm in 6.5 mins. The technique has been applied extensively in rat prostate tumors and is now demonstrated in the rat breast 13762NF adenocarcinoma. When anesthetized rats breathed 33% oxygen, mean baseline pO2 was in the range 17 ± 2 (se) torr to 74 ± 4 torr with mean value for nine tumors 46 ± 8 torr. However, small tumors (< 2.2 cm3) were significantly better oxygenated with mean pO2 = 63 ± 7 torr than large tumors (> 2.4 cm3) with mean pO2 24 ± 5 torr (p< 0.002). Switching the inhaled gas to oxygen or carbogen produced a significant and rapid increase in mean pO2 for both small and larger tumors (p< 0.05). Given the increasing evidence that tumor oxygenation is related to therapeutic outcome, we believe this approach to measuring tumor oxygen dynamics can be of value in predicting response to therapy, evaluating adjuvant interventions designed to modulate response to therapy, and in providing "Prognostic Radiology".

KW - Breast tumor

KW - Carbogen

KW - Hexafluorobenzene

KW - Hypoxia

KW - Magnetic resonance imaging

KW - Oxygen

UR - http://www.scopus.com/inward/record.url?scp=0013110881&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0013110881&partnerID=8YFLogxK

M3 - Article

C2 - 12625774

AN - SCOPUS:0013110881

VL - 1

SP - 471

EP - 478

JO - Technology in Cancer Research and Treatment

JF - Technology in Cancer Research and Treatment

SN - 1533-0346

IS - 6

ER -