TY - JOUR
T1 - Dynamic breast tumor oximetry
T2 - The development of prognostic radiology
AU - Song, Yulin
AU - Constantinescu, Anca
AU - Mason, Ralph P.
PY - 2002/12
Y1 - 2002/12
N2 - A novel pre clinical approach to evaluating tumor oxygen dynamics was recently introduced (Am. J. Clin. Oncol. 24, 462-466 (2001)). FREDOM (Fluorocarbon Relaxometry using Echo planar imaging for Dynamic Oxygen Mapping) allows maps of tumor pO2 including 50-150 individual locations simultaneously to be produced with typical in plane resolution of 1.25 mm in 6.5 mins. The technique has been applied extensively in rat prostate tumors and is now demonstrated in the rat breast 13762NF adenocarcinoma. When anesthetized rats breathed 33% oxygen, mean baseline pO2 was in the range 17 ± 2 (se) torr to 74 ± 4 torr with mean value for nine tumors 46 ± 8 torr. However, small tumors (< 2.2 cm3) were significantly better oxygenated with mean pO2 = 63 ± 7 torr than large tumors (> 2.4 cm3) with mean pO2 24 ± 5 torr (p< 0.002). Switching the inhaled gas to oxygen or carbogen produced a significant and rapid increase in mean pO2 for both small and larger tumors (p< 0.05). Given the increasing evidence that tumor oxygenation is related to therapeutic outcome, we believe this approach to measuring tumor oxygen dynamics can be of value in predicting response to therapy, evaluating adjuvant interventions designed to modulate response to therapy, and in providing "Prognostic Radiology".
AB - A novel pre clinical approach to evaluating tumor oxygen dynamics was recently introduced (Am. J. Clin. Oncol. 24, 462-466 (2001)). FREDOM (Fluorocarbon Relaxometry using Echo planar imaging for Dynamic Oxygen Mapping) allows maps of tumor pO2 including 50-150 individual locations simultaneously to be produced with typical in plane resolution of 1.25 mm in 6.5 mins. The technique has been applied extensively in rat prostate tumors and is now demonstrated in the rat breast 13762NF adenocarcinoma. When anesthetized rats breathed 33% oxygen, mean baseline pO2 was in the range 17 ± 2 (se) torr to 74 ± 4 torr with mean value for nine tumors 46 ± 8 torr. However, small tumors (< 2.2 cm3) were significantly better oxygenated with mean pO2 = 63 ± 7 torr than large tumors (> 2.4 cm3) with mean pO2 24 ± 5 torr (p< 0.002). Switching the inhaled gas to oxygen or carbogen produced a significant and rapid increase in mean pO2 for both small and larger tumors (p< 0.05). Given the increasing evidence that tumor oxygenation is related to therapeutic outcome, we believe this approach to measuring tumor oxygen dynamics can be of value in predicting response to therapy, evaluating adjuvant interventions designed to modulate response to therapy, and in providing "Prognostic Radiology".
KW - Breast tumor
KW - Carbogen
KW - Hexafluorobenzene
KW - Hypoxia
KW - Magnetic resonance imaging
KW - Oxygen
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U2 - 10.1177/153303460200100607
DO - 10.1177/153303460200100607
M3 - Article
C2 - 12625774
AN - SCOPUS:0013110881
SN - 1533-0346
VL - 1
SP - 471
EP - 478
JO - Technology in Cancer Research and Treatment
JF - Technology in Cancer Research and Treatment
IS - 6
ER -