Dynamic cerebral autoregulation reproducibility is affected by physiological variability

Marit L. Sanders, Jan Willem J. Elting, Ronney B. Panerai, Marcel Aries, Edson Bor-Seng-Shu, Alexander Caicedo, Max Chacon, Erik D. Gommer, Sabine Van Huffel, José L. Jara, Kyriaki Kostoglou, Adam Mahdi, Vasilis Z. Marmarelis, Georgios D. Mitsis, Martin Müller, Dragana Nikolic, Ricardo C. Nogueira, Stephen J. Payne, Corina Puppo, Dae C. Shin & 5 others David M. Simpson, Takashi Tarumi Ph.D., Bernardo Yelicich, Rong Zhang, Jurgen A.H.R. Claassen

Research output: Contribution to journalArticle

Abstract

Parameters describing dynamic cerebral autoregulation (DCA) have limited reproducibility. In an international, multi-center study, we evaluated the influence of multiple analytical methods on the reproducibility of DCA. Fourteen participating centers analyzed repeated measurements from 75 healthy subjects, consisting of 5 min of spontaneous fluctuations in blood pressure and cerebral blood flow velocity signals, based on their usual methods of analysis. DCA methods were grouped into three broad categories, depending on output types: (1) transfer function analysis (TFA); (2) autoregulation index (ARI); and (3) correlation coefficient. Only TFA gain in the low frequency (LF) band showed good reproducibility in approximately half of the estimates of gain, defined as an intraclass correlation coefficient (ICC) of > 0.6. None of the other DCA metrics had good reproducibility. For TFA-like and ARI-like methods, ICCs were lower than values obtained with surrogate data (p < 0.05). For TFA-like methods, ICCs were lower for the very LF band (gain 0.38 ± 0.057, phase 0.17 ± 0.13) than for LF band (gain 0.59 ± 0.078, phase 0.39 ± 0.11, p ≤ 0.001 for both gain and phase). For ARI-like methods, the mean ICC was 0.30 ± 0.12 and for the correlation methods 0.24 ± 0.23. Based on comparisons with ICC estimates obtained from surrogate data, we conclude that physiological variability or non-stationarity is likely to be the main reason for the poor reproducibility of DCA parameters.

Original languageEnglish (US)
Article number865
JournalFrontiers in Physiology
Volume10
Issue numberJUL
DOIs
StatePublished - Jan 1 2019

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Homeostasis
Cerebrovascular Circulation
Blood Flow Velocity
Healthy Volunteers
Blood Pressure

Keywords

  • ARI index
  • Cerebral blood flow
  • Cerebral hemodynamics
  • Transcranial doppler
  • Transfer function analysis

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Sanders, M. L., Elting, J. W. J., Panerai, R. B., Aries, M., Bor-Seng-Shu, E., Caicedo, A., ... Claassen, J. A. H. R. (2019). Dynamic cerebral autoregulation reproducibility is affected by physiological variability. Frontiers in Physiology, 10(JUL), [865]. https://doi.org/10.3389/fphys.2019.00865

Dynamic cerebral autoregulation reproducibility is affected by physiological variability. / Sanders, Marit L.; Elting, Jan Willem J.; Panerai, Ronney B.; Aries, Marcel; Bor-Seng-Shu, Edson; Caicedo, Alexander; Chacon, Max; Gommer, Erik D.; Van Huffel, Sabine; Jara, José L.; Kostoglou, Kyriaki; Mahdi, Adam; Marmarelis, Vasilis Z.; Mitsis, Georgios D.; Müller, Martin; Nikolic, Dragana; Nogueira, Ricardo C.; Payne, Stephen J.; Puppo, Corina; Shin, Dae C.; Simpson, David M.; Tarumi Ph.D., Takashi; Yelicich, Bernardo; Zhang, Rong; Claassen, Jurgen A.H.R.

In: Frontiers in Physiology, Vol. 10, No. JUL, 865, 01.01.2019.

Research output: Contribution to journalArticle

Sanders, ML, Elting, JWJ, Panerai, RB, Aries, M, Bor-Seng-Shu, E, Caicedo, A, Chacon, M, Gommer, ED, Van Huffel, S, Jara, JL, Kostoglou, K, Mahdi, A, Marmarelis, VZ, Mitsis, GD, Müller, M, Nikolic, D, Nogueira, RC, Payne, SJ, Puppo, C, Shin, DC, Simpson, DM, Tarumi Ph.D., T, Yelicich, B, Zhang, R & Claassen, JAHR 2019, 'Dynamic cerebral autoregulation reproducibility is affected by physiological variability', Frontiers in Physiology, vol. 10, no. JUL, 865. https://doi.org/10.3389/fphys.2019.00865
Sanders ML, Elting JWJ, Panerai RB, Aries M, Bor-Seng-Shu E, Caicedo A et al. Dynamic cerebral autoregulation reproducibility is affected by physiological variability. Frontiers in Physiology. 2019 Jan 1;10(JUL). 865. https://doi.org/10.3389/fphys.2019.00865
Sanders, Marit L. ; Elting, Jan Willem J. ; Panerai, Ronney B. ; Aries, Marcel ; Bor-Seng-Shu, Edson ; Caicedo, Alexander ; Chacon, Max ; Gommer, Erik D. ; Van Huffel, Sabine ; Jara, José L. ; Kostoglou, Kyriaki ; Mahdi, Adam ; Marmarelis, Vasilis Z. ; Mitsis, Georgios D. ; Müller, Martin ; Nikolic, Dragana ; Nogueira, Ricardo C. ; Payne, Stephen J. ; Puppo, Corina ; Shin, Dae C. ; Simpson, David M. ; Tarumi Ph.D., Takashi ; Yelicich, Bernardo ; Zhang, Rong ; Claassen, Jurgen A.H.R. / Dynamic cerebral autoregulation reproducibility is affected by physiological variability. In: Frontiers in Physiology. 2019 ; Vol. 10, No. JUL.
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AU - Bor-Seng-Shu, Edson

AU - Caicedo, Alexander

AU - Chacon, Max

AU - Gommer, Erik D.

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AU - Nikolic, Dragana

AU - Nogueira, Ricardo C.

AU - Payne, Stephen J.

AU - Puppo, Corina

AU - Shin, Dae C.

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