TY - JOUR
T1 - Dynamic characteristics of heart rate control by the autonomic nervous system in rats
AU - Mizuno, Masaki
AU - Kawada, Toru
AU - Kamiya, Atsunori
AU - Miyamoto, Tadayoshi
AU - Shimizu, Shuji
AU - Shishido, Toshiaki
AU - Smith, Scott A.
AU - Sugimachi, Masaru
PY - 2010/9/1
Y1 - 2010/9/1
N2 - We estimated the transfer function of autonomic heart rate (HR) control by using random binary sympathetic or vagal nerve stimulation in anaesthetized rats. The transfer function from sympathetic stimulation to HR response approximated a second-order, low-pass filter with a lag time (gain, 4.29 ± 1.55 beats min-1 Hz-1; natural frequency, 0.07 ± 0.03 Hz; damping coefficient, 1.96 ± 0.64; and lag time, 0.73 ± 0.12 s). The transfer function from vagal stimulation to HR response approximated a first-order, low-pass filter with a lag time (gain, 8.84 ± 4.51 beats min-1 Hz-1; corner frequency, 0.12 ± 0.06 Hz; and lag time, 0.12 ± 0.08 s). These results suggest that the dynamic characteristics of HR control by the autonomic nervous system in rats are similar to those of larger mammals.
AB - We estimated the transfer function of autonomic heart rate (HR) control by using random binary sympathetic or vagal nerve stimulation in anaesthetized rats. The transfer function from sympathetic stimulation to HR response approximated a second-order, low-pass filter with a lag time (gain, 4.29 ± 1.55 beats min-1 Hz-1; natural frequency, 0.07 ± 0.03 Hz; damping coefficient, 1.96 ± 0.64; and lag time, 0.73 ± 0.12 s). The transfer function from vagal stimulation to HR response approximated a first-order, low-pass filter with a lag time (gain, 8.84 ± 4.51 beats min-1 Hz-1; corner frequency, 0.12 ± 0.06 Hz; and lag time, 0.12 ± 0.08 s). These results suggest that the dynamic characteristics of HR control by the autonomic nervous system in rats are similar to those of larger mammals.
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U2 - 10.1113/expphysiol.2010.053090
DO - 10.1113/expphysiol.2010.053090
M3 - Article
C2 - 20511330
AN - SCOPUS:77955814987
SN - 0958-0670
VL - 95
SP - 919
EP - 925
JO - Experimental Physiology
JF - Experimental Physiology
IS - 9
ER -