Dynamic gut microbiome changes following regional intestinal lymphatic obstruction in primates

F. Becker; F. N.E. Gavins; J. Fontenot; P. Jordan; J. Y. Yun; R. Scott; P. R. Polk; R. E. Friday; M. Boktor; M. Musso; E. Romero; S. Boudreaux; J. Simmons; D. L. Hasselschwert; J. E. Goetzmann; J. Vanchiere; U. Cvek; M. Trutschl; P. Kilgore; J. S. Alexander

doi:10.1016/j.pathophys.2019.06.004

Dynamic gut microbiome changes following regional intestinal lymphatic obstruction in primates

F. Becker, F. N.E. Gavins, J. Fontenot, P. Jordan, J. Y. Yun, R. Scott, P. R. Polk, R. E. Friday, M. Boktor, M. Musso, E. Romero, S. Boudreaux, J. Simmons, D. L. Hasselschwert, J. E. Goetzmann, J. Vanchiere, U. Cvek, M. Trutschl, P. Kilgore, J. S. Alexander

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The pathogenesis of inflammatory bowel disease (IBD) has been linked with lymphostasis, but whether and how lymphatic obstruction might disturb the intestinal microbiome in the setting of Crohn's Disease (CD) is currently unknown. We employed a new model of CD in African Green monkeys, termed ‘ATLAS’ (African green monkey truncation of lymphatics with obstruction and sclerosis), to evaluate how gut lymphatic obstruction alters the intestinal microbiome at 7, 21 and 61 days. Remarkable changes in several microbial sub- groupings within the gut microbiome were observed at 7 days post-ATLAS compared to controls including increased abundance of Prevotellaceae and Bacteroidetes-Prevotella-Porphyromonas (BPP), which may contribute to disease activity in this model of gut injury. To the best of our knowledge, these findings represent the first report linking lymphatic structural/gut functional changes with alterations in the gut microbiome as they may relate to the pathophysiology of CD.

Original language	English (US)
Pages (from-to)	253-261
Number of pages	9
Journal	Pathophysiology
Volume	26
Issue number	3-4
DOIs	https://doi.org/10.1016/j.pathophys.2019.06.004
State	Published - Sep 1 2019
Externally published	Yes

Keywords

Crohn's disease
Inflammatory bowel disease
Lymphatic obstruction
Lymphatics
Microbiome
Non-human primate

ASJC Scopus subject areas

Pathology and Forensic Medicine
Physiology (medical)

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10.1016/j.pathophys.2019.06.004

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Becker, F., Gavins, F. N. E., Fontenot, J., Jordan, P., Yun, J. Y., Scott, R., Polk, P. R., Friday, R. E., Boktor, M., Musso, M., Romero, E., Boudreaux, S., Simmons, J., Hasselschwert, D. L., Goetzmann, J. E., Vanchiere, J., Cvek, U., Trutschl, M., Kilgore, P., & Alexander, J. S. (2019). Dynamic gut microbiome changes following regional intestinal lymphatic obstruction in primates. Pathophysiology, 26(3-4), 253-261. https://doi.org/10.1016/j.pathophys.2019.06.004

Becker, F, Gavins, FNE, Fontenot, J, Jordan, P, Yun, JY, Scott, R, Polk, PR, Friday, RE, Boktor, M, Musso, M, Romero, E, Boudreaux, S, Simmons, J, Hasselschwert, DL, Goetzmann, JE, Vanchiere, J, Cvek, U, Trutschl, M, Kilgore, P & Alexander, JS 2019, 'Dynamic gut microbiome changes following regional intestinal lymphatic obstruction in primates', Pathophysiology, vol. 26, no. 3-4, pp. 253-261. https://doi.org/10.1016/j.pathophys.2019.06.004

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title = "Dynamic gut microbiome changes following regional intestinal lymphatic obstruction in primates",

abstract = "The pathogenesis of inflammatory bowel disease (IBD) has been linked with lymphostasis, but whether and how lymphatic obstruction might disturb the intestinal microbiome in the setting of Crohn's Disease (CD) is currently unknown. We employed a new model of CD in African Green monkeys, termed {\textquoteleft}ATLAS{\textquoteright} (African green monkey truncation of lymphatics with obstruction and sclerosis), to evaluate how gut lymphatic obstruction alters the intestinal microbiome at 7, 21 and 61 days. Remarkable changes in several microbial sub- groupings within the gut microbiome were observed at 7 days post-ATLAS compared to controls including increased abundance of Prevotellaceae and Bacteroidetes-Prevotella-Porphyromonas (BPP), which may contribute to disease activity in this model of gut injury. To the best of our knowledge, these findings represent the first report linking lymphatic structural/gut functional changes with alterations in the gut microbiome as they may relate to the pathophysiology of CD.",

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AU - Hasselschwert, D. L.

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AU - Kilgore, P.

AU - Alexander, J. S.

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AB - The pathogenesis of inflammatory bowel disease (IBD) has been linked with lymphostasis, but whether and how lymphatic obstruction might disturb the intestinal microbiome in the setting of Crohn's Disease (CD) is currently unknown. We employed a new model of CD in African Green monkeys, termed ‘ATLAS’ (African green monkey truncation of lymphatics with obstruction and sclerosis), to evaluate how gut lymphatic obstruction alters the intestinal microbiome at 7, 21 and 61 days. Remarkable changes in several microbial sub- groupings within the gut microbiome were observed at 7 days post-ATLAS compared to controls including increased abundance of Prevotellaceae and Bacteroidetes-Prevotella-Porphyromonas (BPP), which may contribute to disease activity in this model of gut injury. To the best of our knowledge, these findings represent the first report linking lymphatic structural/gut functional changes with alterations in the gut microbiome as they may relate to the pathophysiology of CD.

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Dynamic gut microbiome changes following regional intestinal lymphatic obstruction in primates

Abstract

Keywords

ASJC Scopus subject areas

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