Dynamic relation of changes in weight and indices of fat distribution with cardiac structure and function: The dallas heart study

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background-Obesity may increase heart failure risk through cardiac remodeling. Cross-sectional associations between adiposity and cardiac structure and function have been elucidated, but the impact of longitudinal changes in adiposity on cardiac remodeling is less well understood. Methods and Results-Participants in the Dallas Heart Study without cardiovascular disease or left ventricular dysfunction underwent assessment of body weight, anthropometrics, and cardiac magnetic resonance imaging at baseline and 7 years later. Associations between changes in indices of generalized and central adiposity with changes in left ventricular mass, volume, mass/ volume ratio (concentricity), wall thickness, and ejection fraction were assessed using multivariable linear regression. The study cohort (n=1262) mean age was 44 years with 57% women, 44% black, and 36% obese participants. At follow-up, 41% had ≥5% weight gain, and 15% had ≥5% weight loss. Greater weight gain was associated with younger age, lower risk factor burden, and lower body mass index at baseline. In multivariable models adjusting for age, sex, race, comorbid conditions at baseline and followup, baseline adiposity, and cardiac measurement, increasing weight was associated with increases in left ventricular mass (β=0.10, P < 0.0001), wall thickness (β=0.10, P < 0.0001), and concentricity (β=0.06, P=0.002), with modest effects on end-diastolic volume (β=0.04, P=0.044) and ejection fraction (β=0.05, P=0.046). Similar results were seen with other adiposity indices. Conclusions-Concentric left ventricular remodeling is the predominant phenotype linked to increasing adiposity in middle age. Our findings support the importance of weight management to prevent secular changes in adiposity, concentric remodeling, and eventual heart failure over time.

Original languageEnglish (US)
Article numbere005897
JournalJournal of the American Heart Association
Volume6
Issue number7
DOIs
StatePublished - Jul 1 2017

Fingerprint

Adiposity
Fats
Weights and Measures
Weight Gain
Heart Failure
Ventricular Remodeling
Left Ventricular Dysfunction
Weight Loss
Linear Models
Body Mass Index
Cohort Studies
Cardiovascular Diseases
Obesity
Body Weight
Magnetic Resonance Imaging
Phenotype

Keywords

  • Adipose tissue
  • Body mass index
  • Cardiac remodeling
  • Dual x-ray absorptiometry
  • Magnetic resonance imaging
  • Obesity
  • Visceral adipose tissue
  • Waist circumference

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{25d2e8ba1ca742f7bc4ce44ae951e760,
title = "Dynamic relation of changes in weight and indices of fat distribution with cardiac structure and function: The dallas heart study",
abstract = "Background-Obesity may increase heart failure risk through cardiac remodeling. Cross-sectional associations between adiposity and cardiac structure and function have been elucidated, but the impact of longitudinal changes in adiposity on cardiac remodeling is less well understood. Methods and Results-Participants in the Dallas Heart Study without cardiovascular disease or left ventricular dysfunction underwent assessment of body weight, anthropometrics, and cardiac magnetic resonance imaging at baseline and 7 years later. Associations between changes in indices of generalized and central adiposity with changes in left ventricular mass, volume, mass/ volume ratio (concentricity), wall thickness, and ejection fraction were assessed using multivariable linear regression. The study cohort (n=1262) mean age was 44 years with 57{\%} women, 44{\%} black, and 36{\%} obese participants. At follow-up, 41{\%} had ≥5{\%} weight gain, and 15{\%} had ≥5{\%} weight loss. Greater weight gain was associated with younger age, lower risk factor burden, and lower body mass index at baseline. In multivariable models adjusting for age, sex, race, comorbid conditions at baseline and followup, baseline adiposity, and cardiac measurement, increasing weight was associated with increases in left ventricular mass (β=0.10, P < 0.0001), wall thickness (β=0.10, P < 0.0001), and concentricity (β=0.06, P=0.002), with modest effects on end-diastolic volume (β=0.04, P=0.044) and ejection fraction (β=0.05, P=0.046). Similar results were seen with other adiposity indices. Conclusions-Concentric left ventricular remodeling is the predominant phenotype linked to increasing adiposity in middle age. Our findings support the importance of weight management to prevent secular changes in adiposity, concentric remodeling, and eventual heart failure over time.",
keywords = "Adipose tissue, Body mass index, Cardiac remodeling, Dual x-ray absorptiometry, Magnetic resonance imaging, Obesity, Visceral adipose tissue, Waist circumference",
author = "Bryan Wilner and Sonia Garg and Ayers, {Colby R.} and Maroules, {Christopher D.} and McColl, {Roderick W} and Matulevicius, {Susan A} and {de Lemos}, {James A} and Drazner, {Mark H} and Peshock, {Ronald M} and Neeland, {Ian J}",
year = "2017",
month = "7",
day = "1",
doi = "10.1161/JAHA.117.005897",
language = "English (US)",
volume = "6",
journal = "Journal of the American Heart Association",
issn = "2047-9980",
publisher = "Wiley-Blackwell",
number = "7",

}

TY - JOUR

T1 - Dynamic relation of changes in weight and indices of fat distribution with cardiac structure and function

T2 - The dallas heart study

AU - Wilner, Bryan

AU - Garg, Sonia

AU - Ayers, Colby R.

AU - Maroules, Christopher D.

AU - McColl, Roderick W

AU - Matulevicius, Susan A

AU - de Lemos, James A

AU - Drazner, Mark H

AU - Peshock, Ronald M

AU - Neeland, Ian J

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Background-Obesity may increase heart failure risk through cardiac remodeling. Cross-sectional associations between adiposity and cardiac structure and function have been elucidated, but the impact of longitudinal changes in adiposity on cardiac remodeling is less well understood. Methods and Results-Participants in the Dallas Heart Study without cardiovascular disease or left ventricular dysfunction underwent assessment of body weight, anthropometrics, and cardiac magnetic resonance imaging at baseline and 7 years later. Associations between changes in indices of generalized and central adiposity with changes in left ventricular mass, volume, mass/ volume ratio (concentricity), wall thickness, and ejection fraction were assessed using multivariable linear regression. The study cohort (n=1262) mean age was 44 years with 57% women, 44% black, and 36% obese participants. At follow-up, 41% had ≥5% weight gain, and 15% had ≥5% weight loss. Greater weight gain was associated with younger age, lower risk factor burden, and lower body mass index at baseline. In multivariable models adjusting for age, sex, race, comorbid conditions at baseline and followup, baseline adiposity, and cardiac measurement, increasing weight was associated with increases in left ventricular mass (β=0.10, P < 0.0001), wall thickness (β=0.10, P < 0.0001), and concentricity (β=0.06, P=0.002), with modest effects on end-diastolic volume (β=0.04, P=0.044) and ejection fraction (β=0.05, P=0.046). Similar results were seen with other adiposity indices. Conclusions-Concentric left ventricular remodeling is the predominant phenotype linked to increasing adiposity in middle age. Our findings support the importance of weight management to prevent secular changes in adiposity, concentric remodeling, and eventual heart failure over time.

AB - Background-Obesity may increase heart failure risk through cardiac remodeling. Cross-sectional associations between adiposity and cardiac structure and function have been elucidated, but the impact of longitudinal changes in adiposity on cardiac remodeling is less well understood. Methods and Results-Participants in the Dallas Heart Study without cardiovascular disease or left ventricular dysfunction underwent assessment of body weight, anthropometrics, and cardiac magnetic resonance imaging at baseline and 7 years later. Associations between changes in indices of generalized and central adiposity with changes in left ventricular mass, volume, mass/ volume ratio (concentricity), wall thickness, and ejection fraction were assessed using multivariable linear regression. The study cohort (n=1262) mean age was 44 years with 57% women, 44% black, and 36% obese participants. At follow-up, 41% had ≥5% weight gain, and 15% had ≥5% weight loss. Greater weight gain was associated with younger age, lower risk factor burden, and lower body mass index at baseline. In multivariable models adjusting for age, sex, race, comorbid conditions at baseline and followup, baseline adiposity, and cardiac measurement, increasing weight was associated with increases in left ventricular mass (β=0.10, P < 0.0001), wall thickness (β=0.10, P < 0.0001), and concentricity (β=0.06, P=0.002), with modest effects on end-diastolic volume (β=0.04, P=0.044) and ejection fraction (β=0.05, P=0.046). Similar results were seen with other adiposity indices. Conclusions-Concentric left ventricular remodeling is the predominant phenotype linked to increasing adiposity in middle age. Our findings support the importance of weight management to prevent secular changes in adiposity, concentric remodeling, and eventual heart failure over time.

KW - Adipose tissue

KW - Body mass index

KW - Cardiac remodeling

KW - Dual x-ray absorptiometry

KW - Magnetic resonance imaging

KW - Obesity

KW - Visceral adipose tissue

KW - Waist circumference

UR - http://www.scopus.com/inward/record.url?scp=85025443491&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85025443491&partnerID=8YFLogxK

U2 - 10.1161/JAHA.117.005897

DO - 10.1161/JAHA.117.005897

M3 - Article

C2 - 28724650

AN - SCOPUS:85025443491

VL - 6

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

SN - 2047-9980

IS - 7

M1 - e005897

ER -