Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure

Takehiro Kamo, Hiroshi Akazawa, Wataru Suda, Akiko Saga-Kamo, Yu Shimizu, Hiroki Yagi, Qing Liu, Seitaro Nomura, Atsuhiko T. Naito, Norifumi Takeda, Mutsuo Harada, Haruhiro Toko, Hidetoshi Kumagai, Yuichi Ikeda, Eiki Takimoto, Jun Ichi Suzuki, Kenya Honda, Hidetoshi Morita, Masahira Hattori, Issei Komuro

Research output: Contribution to journalArticle

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Abstract

Emerging evidence has suggested a potential impact of gut microbiota on the pathophysiology of heart failure (HF). However, it is still unknown whether HF is associated with dysbiosis in gut microbiota. We investigated the composition of gut microbiota in patients with HF to elucidate whether gut microbial dysbiosis is associated with HF. We performed 16S ribosomal RNA gene sequencing of fecal samples obtained from 12 HF patients and 12 agematched healthy control (HC) subjects, and analyzed the differences in gut microbiota. We further compared the composition of gut microbiota of 12 HF patients younger than 60 years of age with that of 10 HF patients 60 years of age or older. The composition of gut microbial communities of HF patients was distinct from that of HC subjects in both unweighted and weighted UniFrac analyses. Eubacterium rectale and Dorea longicatena were less abundant in the gut microbiota of HF patients than in that of HC subjects. Compared to younger HF patients, older HF patients had diminished proportions of Bacteroidetes and larger quantities of Proteobacteria. The genus Faecalibacterium was depleted, while Lactobacillus was enriched in the gut microbiota of older HF patients. These results suggest that patients with HF harbor significantly altered gut microbiota, which varies further according to age. New concept of heart-gut axis has a great potential for breakthroughs in the development of novel diagnostic and therapeutic approach for HF.

Original languageEnglish (US)
Article numbere0174099
JournalPLoS One
Volume12
Issue number3
DOIs
StatePublished - Mar 1 2017

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Dysbiosis
heart failure
intestinal microorganisms
Heart Failure
Aging of materials
Healthy Volunteers
Gastrointestinal Microbiome
Eubacterium rectale
Chemical analysis
Eubacterium
16S Ribosomal RNA
Bacteroidetes
RNA Sequence Analysis
Proteobacteria
Lactobacillus

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Kamo, T., Akazawa, H., Suda, W., Saga-Kamo, A., Shimizu, Y., Yagi, H., ... Komuro, I. (2017). Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure. PLoS One, 12(3), [e0174099]. https://doi.org/10.1371/journal.pone.0174099

Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure. / Kamo, Takehiro; Akazawa, Hiroshi; Suda, Wataru; Saga-Kamo, Akiko; Shimizu, Yu; Yagi, Hiroki; Liu, Qing; Nomura, Seitaro; Naito, Atsuhiko T.; Takeda, Norifumi; Harada, Mutsuo; Toko, Haruhiro; Kumagai, Hidetoshi; Ikeda, Yuichi; Takimoto, Eiki; Suzuki, Jun Ichi; Honda, Kenya; Morita, Hidetoshi; Hattori, Masahira; Komuro, Issei.

In: PLoS One, Vol. 12, No. 3, e0174099, 01.03.2017.

Research output: Contribution to journalArticle

Kamo, T, Akazawa, H, Suda, W, Saga-Kamo, A, Shimizu, Y, Yagi, H, Liu, Q, Nomura, S, Naito, AT, Takeda, N, Harada, M, Toko, H, Kumagai, H, Ikeda, Y, Takimoto, E, Suzuki, JI, Honda, K, Morita, H, Hattori, M & Komuro, I 2017, 'Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure', PLoS One, vol. 12, no. 3, e0174099. https://doi.org/10.1371/journal.pone.0174099
Kamo, Takehiro ; Akazawa, Hiroshi ; Suda, Wataru ; Saga-Kamo, Akiko ; Shimizu, Yu ; Yagi, Hiroki ; Liu, Qing ; Nomura, Seitaro ; Naito, Atsuhiko T. ; Takeda, Norifumi ; Harada, Mutsuo ; Toko, Haruhiro ; Kumagai, Hidetoshi ; Ikeda, Yuichi ; Takimoto, Eiki ; Suzuki, Jun Ichi ; Honda, Kenya ; Morita, Hidetoshi ; Hattori, Masahira ; Komuro, Issei. / Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure. In: PLoS One. 2017 ; Vol. 12, No. 3.
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