Dyslipidemia links obesity to early cerebral neurochemical alterations

Andreana P. Haley, Mitzi M. Gonzales, Takashi Tarumi, Hirofumi Tanaka

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective To examine the role of hypertension, hyperglycemia, and dyslipidemia in potentially accounting for obesity-related brain vulnerability in the form of altered cerebral neurochemistry. Design and Methods Sixty-four adults, ages 40-60 years, underwent a health screen and proton magnetic resonance spectroscopy (1H MRS) of occipitoparietal gray matter to measure N-acetyl aspartate (NAA), choline (Cho), myo-inositol (mI), and glutamate (Glu) relative to creatine (Cr). The causal steps approach and nonparametric bootstrapping were utilized to assess if fasting glucose, mean arterial pressure or peripheral lipid/lipoprotein levels mediate the relationship between body mass index (BMI) and cerebral neurochemistry. Results Higher BMI was significantly related to higher mI/Cr, independent of age and sex. BMI was also significantly related to two of the proposed mediators, triglyceride, and HDL-cholesterol, which were also independently related to increased mI/Cr. Finally, the relationship between BMI and mI/Cr was significantly attenuated after inclusion of triglyceride and HDL-cholesterol into the model, one at a time, indicating statistical mediation. Conclusions Higher triglyceride and lower HDL levels statistically account for the association between BMI and myo-inositol, pointing toward a potentially critical role for dyslipidemia in the development of cerebral neurochemical alterations in obesity.

Original languageEnglish (US)
Pages (from-to)2007-2013
Number of pages7
JournalObesity
Volume21
Issue number10
DOIs
StatePublished - Oct 1 2013

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Inositol
Dyslipidemias
Creatine
Body Mass Index
Obesity
Neurochemistry
Triglycerides
HDL Cholesterol
Choline
Hyperglycemia
Lipoproteins
Glutamic Acid
Fasting
Arterial Pressure
Hypertension
Lipids
Glucose
Health
Brain
Proton Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Haley, A. P., Gonzales, M. M., Tarumi, T., & Tanaka, H. (2013). Dyslipidemia links obesity to early cerebral neurochemical alterations. Obesity, 21(10), 2007-2013. https://doi.org/10.1002/oby.20332

Dyslipidemia links obesity to early cerebral neurochemical alterations. / Haley, Andreana P.; Gonzales, Mitzi M.; Tarumi, Takashi; Tanaka, Hirofumi.

In: Obesity, Vol. 21, No. 10, 01.10.2013, p. 2007-2013.

Research output: Contribution to journalArticle

Haley, AP, Gonzales, MM, Tarumi, T & Tanaka, H 2013, 'Dyslipidemia links obesity to early cerebral neurochemical alterations', Obesity, vol. 21, no. 10, pp. 2007-2013. https://doi.org/10.1002/oby.20332
Haley AP, Gonzales MM, Tarumi T, Tanaka H. Dyslipidemia links obesity to early cerebral neurochemical alterations. Obesity. 2013 Oct 1;21(10):2007-2013. https://doi.org/10.1002/oby.20332
Haley, Andreana P. ; Gonzales, Mitzi M. ; Tarumi, Takashi ; Tanaka, Hirofumi. / Dyslipidemia links obesity to early cerebral neurochemical alterations. In: Obesity. 2013 ; Vol. 21, No. 10. pp. 2007-2013.
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