Dyspoietic changes associated with hepatosplenic T-cell lymphoma are not a manifestation of a myelodysplastic syndrome: Analysis of 25 patients

Mariko Yabe, L. Jeffrey Medeiros, Guilin Tang, Sa A. Wang, Keyur P. Patel, Mark Routbort, Govind Bhagat, Carlos E. Bueso-Ramos, Jeffrey L. Jorgensen, Rajyalakshmi Luthra, Weina Chen, Tariq Muzzafar, Rashmi Kanagal-Shamanna, Joseph D. Khoury, Yahya Daneshbod, Masoud Davanlou, Shaoying Li, Ken H. Young, Roberto N. Miranda

Research output: Contribution to journalArticle

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Abstract

Hepatosplenic T-cell lymphoma (HSTCL) is a rare T-cell lymphoma commonly associated with cytopenias. The pathogenesis of cytopenias in patients with HSTCL is not well defined, although the presence of dyspoietic hematopoietic cells and the common association with trisomy 8 raise the possibility of an associated myelodysplastic syndrome (MDS). In 25 bone marrow specimens involved by HSTCL, we systematically assessed for morphologic features of dyspoiesis and correlated the findings with peripheral cytopenia(s), cytogenetic findings, and detection of chromosome 8 by fluorescence in situ hybridization. The median patient age was 33 years. One patient had a history of MDS diagnosed 1 year prior to the diagnosis of HSTCL. Thirteen (54%) patients had anemia less than 100 g/L, 10 (53%) of 19 had neutropenia less than 1.8 × 109/L, and 15 (60%) had thrombocytopenia less than 100 × 109/L. Dyspoietic features were identified in 1 to 3 hematopoietic cell lineages in 20 (80%) of 25 patients. Cytogenetic analysis identified trisomy 8 in 7 cases. Patients with trisomy 8 had a lower platelet count, but trisomy 8 was not associated with cytopenias, dyspoietic features, or cytogenetic abnormalities. Combined morphologic and fluorescence in situ hybridization analysis showed that trisomy 8 was restricted to the lymphoma cells, except in the 1 patient with a history of MDS. In conclusion, dyspoietic changes are common in the bone marrow of patients with HSTCL. These changes are not associated with cytopenias or chromosomal abnormalities, suggesting that dyspoiesis in patients with HSTCL is not a manifestation of a MDS.

Original languageEnglish (US)
Pages (from-to)109-117
Number of pages9
JournalHuman Pathology
Volume50
DOIs
StatePublished - Apr 1 2016

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T-Cell Lymphoma
Myelodysplastic Syndromes
Fluorescence In Situ Hybridization
Chromosome Aberrations
Bone Marrow
Chromosomes, Human, Pair 8
Cytogenetic Analysis
Cell Lineage
Neutropenia
Platelet Count
Cytogenetics
Thrombocytopenia
Anemia
Lymphoma
Trisomy Chromosome 8

Keywords

  • Fluorescence in situ hybridization (FISH)
  • Hepatosplenic T-cell lymphoma
  • Myelodysplasia
  • Pancytopenia
  • Trisomy 8

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Dyspoietic changes associated with hepatosplenic T-cell lymphoma are not a manifestation of a myelodysplastic syndrome : Analysis of 25 patients. / Yabe, Mariko; Medeiros, L. Jeffrey; Tang, Guilin; Wang, Sa A.; P. Patel, Keyur; Routbort, Mark; Bhagat, Govind; Bueso-Ramos, Carlos E.; Jorgensen, Jeffrey L.; Luthra, Rajyalakshmi; Chen, Weina; Muzzafar, Tariq; Kanagal-Shamanna, Rashmi; Khoury, Joseph D.; Daneshbod, Yahya; Davanlou, Masoud; Li, Shaoying; Young, Ken H.; Miranda, Roberto N.

In: Human Pathology, Vol. 50, 01.04.2016, p. 109-117.

Research output: Contribution to journalArticle

Yabe, M, Medeiros, LJ, Tang, G, Wang, SA, P. Patel, K, Routbort, M, Bhagat, G, Bueso-Ramos, CE, Jorgensen, JL, Luthra, R, Chen, W, Muzzafar, T, Kanagal-Shamanna, R, Khoury, JD, Daneshbod, Y, Davanlou, M, Li, S, Young, KH & Miranda, RN 2016, 'Dyspoietic changes associated with hepatosplenic T-cell lymphoma are not a manifestation of a myelodysplastic syndrome: Analysis of 25 patients', Human Pathology, vol. 50, pp. 109-117. https://doi.org/10.1016/j.humpath.2015.11.010
Yabe, Mariko ; Medeiros, L. Jeffrey ; Tang, Guilin ; Wang, Sa A. ; P. Patel, Keyur ; Routbort, Mark ; Bhagat, Govind ; Bueso-Ramos, Carlos E. ; Jorgensen, Jeffrey L. ; Luthra, Rajyalakshmi ; Chen, Weina ; Muzzafar, Tariq ; Kanagal-Shamanna, Rashmi ; Khoury, Joseph D. ; Daneshbod, Yahya ; Davanlou, Masoud ; Li, Shaoying ; Young, Ken H. ; Miranda, Roberto N. / Dyspoietic changes associated with hepatosplenic T-cell lymphoma are not a manifestation of a myelodysplastic syndrome : Analysis of 25 patients. In: Human Pathology. 2016 ; Vol. 50. pp. 109-117.
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abstract = "Hepatosplenic T-cell lymphoma (HSTCL) is a rare T-cell lymphoma commonly associated with cytopenias. The pathogenesis of cytopenias in patients with HSTCL is not well defined, although the presence of dyspoietic hematopoietic cells and the common association with trisomy 8 raise the possibility of an associated myelodysplastic syndrome (MDS). In 25 bone marrow specimens involved by HSTCL, we systematically assessed for morphologic features of dyspoiesis and correlated the findings with peripheral cytopenia(s), cytogenetic findings, and detection of chromosome 8 by fluorescence in situ hybridization. The median patient age was 33 years. One patient had a history of MDS diagnosed 1 year prior to the diagnosis of HSTCL. Thirteen (54{\%}) patients had anemia less than 100 g/L, 10 (53{\%}) of 19 had neutropenia less than 1.8 × 109/L, and 15 (60{\%}) had thrombocytopenia less than 100 × 109/L. Dyspoietic features were identified in 1 to 3 hematopoietic cell lineages in 20 (80{\%}) of 25 patients. Cytogenetic analysis identified trisomy 8 in 7 cases. Patients with trisomy 8 had a lower platelet count, but trisomy 8 was not associated with cytopenias, dyspoietic features, or cytogenetic abnormalities. Combined morphologic and fluorescence in situ hybridization analysis showed that trisomy 8 was restricted to the lymphoma cells, except in the 1 patient with a history of MDS. In conclusion, dyspoietic changes are common in the bone marrow of patients with HSTCL. These changes are not associated with cytopenias or chromosomal abnormalities, suggesting that dyspoiesis in patients with HSTCL is not a manifestation of a MDS.",
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T2 - Analysis of 25 patients

AU - Yabe, Mariko

AU - Medeiros, L. Jeffrey

AU - Tang, Guilin

AU - Wang, Sa A.

AU - P. Patel, Keyur

AU - Routbort, Mark

AU - Bhagat, Govind

AU - Bueso-Ramos, Carlos E.

AU - Jorgensen, Jeffrey L.

AU - Luthra, Rajyalakshmi

AU - Chen, Weina

AU - Muzzafar, Tariq

AU - Kanagal-Shamanna, Rashmi

AU - Khoury, Joseph D.

AU - Daneshbod, Yahya

AU - Davanlou, Masoud

AU - Li, Shaoying

AU - Young, Ken H.

AU - Miranda, Roberto N.

PY - 2016/4/1

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N2 - Hepatosplenic T-cell lymphoma (HSTCL) is a rare T-cell lymphoma commonly associated with cytopenias. The pathogenesis of cytopenias in patients with HSTCL is not well defined, although the presence of dyspoietic hematopoietic cells and the common association with trisomy 8 raise the possibility of an associated myelodysplastic syndrome (MDS). In 25 bone marrow specimens involved by HSTCL, we systematically assessed for morphologic features of dyspoiesis and correlated the findings with peripheral cytopenia(s), cytogenetic findings, and detection of chromosome 8 by fluorescence in situ hybridization. The median patient age was 33 years. One patient had a history of MDS diagnosed 1 year prior to the diagnosis of HSTCL. Thirteen (54%) patients had anemia less than 100 g/L, 10 (53%) of 19 had neutropenia less than 1.8 × 109/L, and 15 (60%) had thrombocytopenia less than 100 × 109/L. Dyspoietic features were identified in 1 to 3 hematopoietic cell lineages in 20 (80%) of 25 patients. Cytogenetic analysis identified trisomy 8 in 7 cases. Patients with trisomy 8 had a lower platelet count, but trisomy 8 was not associated with cytopenias, dyspoietic features, or cytogenetic abnormalities. Combined morphologic and fluorescence in situ hybridization analysis showed that trisomy 8 was restricted to the lymphoma cells, except in the 1 patient with a history of MDS. In conclusion, dyspoietic changes are common in the bone marrow of patients with HSTCL. These changes are not associated with cytopenias or chromosomal abnormalities, suggesting that dyspoiesis in patients with HSTCL is not a manifestation of a MDS.

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KW - Trisomy 8

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