E2F1 has both oncogenic and tumor-suppressive properties in a transgenic model

Angela M. Pierce, Robin Schneider-Broussard, Irma B. Gimenez-Conti, Jamie L. Russell, Claudio J. Conti, David G. Johnson

Research output: Contribution to journalArticlepeer-review

134 Scopus citations


Using a transgenic mouse model expressing the E2F1 gene under the control of a keratin 5 (K5) promoter, we previously demonstrated that increased E2F1 activity can promote tumorigenesis by cooperating with either a v-Ha-ras transgene to induce benign skin papillomas or p53 deficiency to induce spontaneous skin carcinomas. We now report that as K5 E2F1 transgenic mice age, they are predisposed to develop spontaneous tumors in a variety of K5-expressing tissues, including the skin, vagina, forestomach, and odontogenic epithelium. On the other hand, K5 E2F1 transgenic mice are found to be resistant to skin tumor development following a two-stage carcinogenesis protocol. Additional experiments suggest that this tumor- suppressive effect of E2F1 occurs at the promotion stage and may involve the induction of apoptosis. These findings demonstrate that increased E2F1 activity can either promote or inhibit tumorigenesis, dependent upon the experimental context.

Original languageEnglish (US)
Pages (from-to)6408-6414
Number of pages7
JournalMolecular and Cellular Biology
Issue number9
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'E2F1 has both oncogenic and tumor-suppressive properties in a transgenic model'. Together they form a unique fingerprint.

Cite this