Early activation of the coagulation system during lower body negative pressure

M. Zaar, P. I. Johansson, L. B. Nielsen, C. G. Crandall, M. Shibasaki, L. Hilsted, N. H. Secher

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We considered that a moderate reduction of the central blood volume (CBV) may activate the coagulation system. Lower body negative pressure (LBNP) is a non-invasive means of reducing CBV and, thereby, simulates haemorrhage. We tested the hypothesis that coagulation markers would increase following moderate hypovolemia by exposing 10 healthy male volunteers to 10 min of 30 mmHg LBNP. Thoracic electrical impedance increased during LBNP (by 2·6 ± 0·7 Ω, mean ± SD; P < 0·001), signifying a reduced CBV. Heart rate was unchanged during LBNP, while mean arterial pressure decreased (84 ± 5 to 80 ± 6 mmHg; P < 0·001) along with stroke volume (114 ± 22 to 96 ± 19 ml min-1; P < 0·001) and cardiac output (6·4 ± 2·0 to 5·5 ± 1·7 l min-1; P < 0·01). Plasma thrombin-antithrombin III complexes increased (TAT, 5 ± 6 to 19 ± 20 μg l-1; P < 0·05), indicating that LBNP activated the thrombin generating part of the coagulation system, while plasma D-dimer was unchanged, signifying that the increased thrombin generation did not cause further intravascular clot formation. The plasma pancreatic polypeptide level decreased (13 ± 11 to 6 ± 8 pmol l-1; P < 0·05), reflecting reduced vagal activity. In conclusion, thrombin generation was activated by a modest decrease in CBV by LBNP in healthy humans independent of the vagal activity.

Original languageEnglish (US)
Pages (from-to)427-430
Number of pages4
JournalClinical Physiology and Functional Imaging
Volume29
Issue number6
DOIs
StatePublished - Nov 2009

Fingerprint

Lower Body Negative Pressure
Blood Volume
Thrombin
Pancreatic Polypeptide
Hypovolemia
Electric Impedance
Cardiac Output
Stroke Volume
Healthy Volunteers
Arterial Pressure
Thorax
Heart Rate
Hemorrhage

Keywords

  • Haemorrhage
  • Hypovolemia
  • Pancreatic polypeptide
  • Thrombin generation
  • Vagal activity

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Early activation of the coagulation system during lower body negative pressure. / Zaar, M.; Johansson, P. I.; Nielsen, L. B.; Crandall, C. G.; Shibasaki, M.; Hilsted, L.; Secher, N. H.

In: Clinical Physiology and Functional Imaging, Vol. 29, No. 6, 11.2009, p. 427-430.

Research output: Contribution to journalArticle

Zaar, M. ; Johansson, P. I. ; Nielsen, L. B. ; Crandall, C. G. ; Shibasaki, M. ; Hilsted, L. ; Secher, N. H. / Early activation of the coagulation system during lower body negative pressure. In: Clinical Physiology and Functional Imaging. 2009 ; Vol. 29, No. 6. pp. 427-430.
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