Early age onset colorectal cancer

Swati G. Patel, Caitlin C. Murphy, Christopher H. Lieu, Heather Hampel

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The incidence and mortality associated with colorectal cancer (CRC) diagnosed in patients under the age of 50 have been steadily increasing. The exact etiology of these epidemiologic trends is unclear. This chapter will provide a comprehensive review on the topic of early age onset colorectal cancer (EAO-CRC), defined as colorectal cancer (CRC) diagnosed in patients under the age of 50. Topics reviewed will include the epidemiology of EAO-CRC around the world, clinical and pathological features of EAO-CRC in contrast to later age onset CRC (CRC diagnosed on those over the age of 50) and the observed molecular and somatic characteristics. This chapter will review the etiologies to EAO-CRC and the established, as well as proposed risk factors for disease. Evidence-based approaches to prevention, early detection, treatment and survivorship will be presented.

Original languageEnglish (US)
Title of host publicationNovel Approaches to Colorectal Cancer
EditorsFranklin G. Berger, C. Richard Boland
PublisherAcademic Press Inc.
Pages1-37
Number of pages37
ISBN (Print)9780128240786
DOIs
StatePublished - Jan 2021

Publication series

NameAdvances in Cancer Research
Volume151
ISSN (Print)0065-230X
ISSN (Electronic)2162-5557

Keywords

  • Adenoma
  • Colonoscopy
  • Colorectal cancer
  • Lynch syndrome

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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