Early Development of Functional Network Segregation Revealed by Connectomic Analysis of the Preterm Human Brain

Miao Cao, Yong He, Zhengjia Dai, Xuhong Liao, Tina Jeon, Minhui Ouyang, Lina Chalak, Yanchao Bi, Nancy Rollins, Qi Dong, Hao Huang

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Human brain functional networks are topologically organized with nontrivial connectivity characteristics such as small-worldness and densely linked hubs to support highly segregated and integrated information processing. However, how they emerge and change at very early developmental phases remains poorly understood. Here, we used resting-state functional MRI and voxel-based graph theory analysis to systematically investigate the topological organization of whole-brain networks in 40 infants aged around 31 to 42 postmenstrual weeks. The functional connectivity strength and heterogeneity increased significantly in primary motor, somatosensory, visual, and auditory regions, but much less in high-order default-mode and executive-control regions. The hub and rich-club structures in primary regions were already present at around 31 postmenstrual weeks and exhibited remarkable expansions with age, accompanied by increased local clustering and shortest path length, indicating a transition from a relatively random to a more organized configuration. Moreover, multivariate pattern analysis using support vector regression revealed that individual brain maturity of preterm babies could be predicted by the network connectivity patterns. Collectively, we highlighted a gradually enhanced functional network segregation manner in the third trimester, which is primarily driven by the rapid increases of functional connectivity of the primary regions, providing crucial insights into the topological development patterns prior to birth.

Original languageEnglish (US)
Pages (from-to)1949-1963
Number of pages15
JournalCerebral cortex (New York, N.Y. : 1991)
Volume27
Issue number3
DOIs
StatePublished - Mar 1 2017

Fingerprint

Connectome
Brain
Executive Function
Third Pregnancy Trimester
Automatic Data Processing
Cluster Analysis
Multivariate Analysis
Magnetic Resonance Imaging
Parturition

Keywords

  • connectome
  • functional connectivity
  • hub
  • preterm
  • rich club

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Early Development of Functional Network Segregation Revealed by Connectomic Analysis of the Preterm Human Brain. / Cao, Miao; He, Yong; Dai, Zhengjia; Liao, Xuhong; Jeon, Tina; Ouyang, Minhui; Chalak, Lina; Bi, Yanchao; Rollins, Nancy; Dong, Qi; Huang, Hao.

In: Cerebral cortex (New York, N.Y. : 1991), Vol. 27, No. 3, 01.03.2017, p. 1949-1963.

Research output: Contribution to journalArticle

Cao, Miao ; He, Yong ; Dai, Zhengjia ; Liao, Xuhong ; Jeon, Tina ; Ouyang, Minhui ; Chalak, Lina ; Bi, Yanchao ; Rollins, Nancy ; Dong, Qi ; Huang, Hao. / Early Development of Functional Network Segregation Revealed by Connectomic Analysis of the Preterm Human Brain. In: Cerebral cortex (New York, N.Y. : 1991). 2017 ; Vol. 27, No. 3. pp. 1949-1963.
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