Abstract
End-stage renal failure secondary to diabetes has increasingly become a health and socioeconomic issue. Diabetic nephropathy is the major cause of death in type I insulin-dependent diabetic patients and accounts for ~25% of all patients beginning hemodialysis in the United States. Once diabetic nephropathy is well established, attempts to modify the relentness downward progression of the disease have been essentially unsuccessful. We focus on the early structural and functional changes that occur as a consequence of diabetic renal disease and examine the evidence for microalbuminuria as an early marker and predictor for future overt diabetic nephropathy. The rationale for different therapeutic interventions to alter the course of early diabetic nephropathy are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 529-545 |
| Number of pages | 17 |
| Journal | Diabetes Care |
| Volume | 9 |
| Issue number | 5 |
| State | Published - 1986 |
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ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Internal Medicine
Cite this
Early diabetic nephropathy : Assessment and potential therapeutic interventions. / Rosenstock, J.; Raskin, Philip.
In: Diabetes Care, Vol. 9, No. 5, 1986, p. 529-545.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Early diabetic nephropathy
T2 - Assessment and potential therapeutic interventions
AU - Rosenstock, J.
AU - Raskin, Philip
PY - 1986
Y1 - 1986
N2 - End-stage renal failure secondary to diabetes has increasingly become a health and socioeconomic issue. Diabetic nephropathy is the major cause of death in type I insulin-dependent diabetic patients and accounts for ~25% of all patients beginning hemodialysis in the United States. Once diabetic nephropathy is well established, attempts to modify the relentness downward progression of the disease have been essentially unsuccessful. We focus on the early structural and functional changes that occur as a consequence of diabetic renal disease and examine the evidence for microalbuminuria as an early marker and predictor for future overt diabetic nephropathy. The rationale for different therapeutic interventions to alter the course of early diabetic nephropathy are discussed.
AB - End-stage renal failure secondary to diabetes has increasingly become a health and socioeconomic issue. Diabetic nephropathy is the major cause of death in type I insulin-dependent diabetic patients and accounts for ~25% of all patients beginning hemodialysis in the United States. Once diabetic nephropathy is well established, attempts to modify the relentness downward progression of the disease have been essentially unsuccessful. We focus on the early structural and functional changes that occur as a consequence of diabetic renal disease and examine the evidence for microalbuminuria as an early marker and predictor for future overt diabetic nephropathy. The rationale for different therapeutic interventions to alter the course of early diabetic nephropathy are discussed.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022475647&partnerID=8YFLogxK
M3 - Article
C2 - 3533477
AN - SCOPUS:0022475647
VL - 9
SP - 529
EP - 545
JO - Diabetes Care
JF - Diabetes Care
SN - 1935-5548
IS - 5
ER -