Early eradication of pseudomonas aeruginosa in patients with cystic fibrosis

Bridget Stuart, Jenny H. Lin, Peter J. Mogayzel

Research output: Contribution to journalReview article

53 Scopus citations

Abstract

Pseudomonas aeruginosa (Pa) is the predominant organism infecting the airways of patients with cystic fibrosis (CF). This organism has an armamentarium of survival mechanisms that allows it to survive in the CF airway. Since colonization and chronic infection with Pa is associated with poorer lung function and increased morbidity and mortality, therapies that can prevent infection could significantly improve the lives of patients with CF. Numerous studies have examined the effects of treatment on the eradication of Pa as a means to ameliorate disease. This article outlines the pathophysiology and clinical implication of Pa acquisition, and reviews the existing treatment regimens aimed at early eradication of Pa in patients with CF.

Original languageEnglish (US)
Pages (from-to)177-184
Number of pages8
JournalPaediatric Respiratory Reviews
Volume11
Issue number3
DOIs
StatePublished - Sep 2010

Keywords

  • Colonization
  • Cystic fibrosis
  • Eradication therapy
  • Inhaled tobramycin
  • Pseudomonas aeruginosa

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

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