Early interfaced neural activity from chronic amputated nerves

Kshitija Garde, Edward Keefer, Barry Botterman, Pedro Galvan, Mario I. Romero-Ortega

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Direct interfacing of transected peripheral nerves with advanced robotic prosthetic devices has been proposed as a strategy for achieving natural motor control and sensory perception of such bionic substitutes, thus fully functionally replacing missing limbs in amputees. Multi-electrode arrays placed in the brain and peripheral nerves have been used successfully to convey neural control of prosthetic devices to the user. However, reactive gliosis, micro hemorrhages, axonopathy and excessive inflammation currently limit their long-term use. Here we demonstrate that enticement of peripheral nerve regeneration through a non-obstructive multi-electrode array, after either acute or chronic nerve amputation, offers a viable alternative to obtain early neural recordings and to enhance long-term interfacing of nerve activity. Non-restrictive electrode arrays placed in the path of regenerating nerve fibers allowed the recording of action potentials as early as 8 days post-implantation with high signal-to-noise ratio, as long as 3 months in some animals, and with minimal inflammation at the nerve tissue-metal electrode interface. Our findings suggest that regenerative multi-electrode arrays of open design allow early and stable interfacing of neural activity from amputated peripheral nerves and might contribute towards conveying full neural control and sensory feedback to users of robotic prosthetic devices.

Original languageEnglish (US)
Article number5
JournalFrontiers in Neuroengineering
Volume2
Issue numberMAY
DOIs
StatePublished - May 26 2009

Fingerprint

Electrodes
Peripheral Nerves
Prosthetics
Robotics
Equipment and Supplies
Bionics
Sensory feedback
Inflammation
Nerve Tissue
Amputees
Sensory Feedback
Nerve Regeneration
Gliosis
Signal-To-Noise Ratio
Conveying
Amputation
Nerve Fibers
Action Potentials
Brain
Signal to noise ratio

Keywords

  • Multi-electrode array
  • Nerve injury
  • Nerve regeneration
  • Neural interface
  • Neuroprostheses

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biophysics
  • Neuroscience (miscellaneous)

Cite this

Early interfaced neural activity from chronic amputated nerves. / Garde, Kshitija; Keefer, Edward; Botterman, Barry; Galvan, Pedro; Romero-Ortega, Mario I.

In: Frontiers in Neuroengineering, Vol. 2, No. MAY, 5, 26.05.2009.

Research output: Contribution to journalArticle

Garde, Kshitija ; Keefer, Edward ; Botterman, Barry ; Galvan, Pedro ; Romero-Ortega, Mario I. / Early interfaced neural activity from chronic amputated nerves. In: Frontiers in Neuroengineering. 2009 ; Vol. 2, No. MAY.
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