Early Mortality Risk Score

Identification of Poor Outcomes Following Upfront Surgery for Resectable Pancreatic Cancer

Charles C. Hsu, Christopher L. Wolfgang, Daniel A. Laheru, Timothy M. Pawlik, Michael J. Swartz, Jordan M. Winter, Raymond Robinson, Barish H. Edil, Amol K. Narang, Michael A. Choti, Ralph H. Hruban, John L. Cameron, Richard D. Schulick, Joseph M. Herman

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background: Identifying pancreatic cancer patients at high risk of early mortality following pancreaticoduodenectomy (PD) is important for treatment decisions in a multidisciplinary setting. This study examines the preoperative predictors of early mortality following PD and combines these variables into an early mortality risk score (EMRS). Methods: Medical records of patients who underwent PD for pancreatic adenocarcinoma at the Johns Hopkins Hospital between 30 August 1993 and 28 February 2005 were reviewed. Cox proportional hazards analysis was performed to identify predictors of early mortality, defined as death at 9 and 12 months. EMRS was constructed from univariate associated risk factors (age >75 years, tumor size ≥3cm, poor differentiation, co-morbid diseases) with each factor assigned 1 point (range of 0-4). EMRS was evaluated as an independent predictor of death at 9 and 12 months. Results: On univariate analysis, risk factors for death at 9 months included age ≥75 years (RR, 1. 6; p =.009), comorbid disease (RR, 1. 5; p = 0. 020), tumor ≥3 cm (RR, 1. 4; P = 0. 050), and poor differentiation (RR, 2. 1; P lt;0. 001). EMRS was associated with early mortality among those who did (p = 0. 038) and did not receive adjuvant treatment (p lt;0. 001). A modified EMRS without tumor differentiation was also associated with early mortality (p lt; 0. 001). Results persisted when reanalyzed using death at 12 months. Conclusions: EMRS may identify patients at risk of early mortality following PD who may be candidates for alternatively sequenced treatment protocols. Prospective validation of this EMRS is needed.

Original languageEnglish (US)
Pages (from-to)753-761
Number of pages9
JournalJournal of Gastrointestinal Surgery
Volume16
Issue number4
DOIs
StatePublished - Apr 2012

Fingerprint

Pancreatic Neoplasms
Mortality
Pancreaticoduodenectomy
Neoplasms
Clinical Protocols
Medical Records
Adenocarcinoma

Keywords

  • Early mortality
  • Pancreatic adenocarcinoma
  • Resectable
  • Risk score

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

Cite this

Hsu, C. C., Wolfgang, C. L., Laheru, D. A., Pawlik, T. M., Swartz, M. J., Winter, J. M., ... Herman, J. M. (2012). Early Mortality Risk Score: Identification of Poor Outcomes Following Upfront Surgery for Resectable Pancreatic Cancer. Journal of Gastrointestinal Surgery, 16(4), 753-761. https://doi.org/10.1007/s11605-011-1811-4

Early Mortality Risk Score : Identification of Poor Outcomes Following Upfront Surgery for Resectable Pancreatic Cancer. / Hsu, Charles C.; Wolfgang, Christopher L.; Laheru, Daniel A.; Pawlik, Timothy M.; Swartz, Michael J.; Winter, Jordan M.; Robinson, Raymond; Edil, Barish H.; Narang, Amol K.; Choti, Michael A.; Hruban, Ralph H.; Cameron, John L.; Schulick, Richard D.; Herman, Joseph M.

In: Journal of Gastrointestinal Surgery, Vol. 16, No. 4, 04.2012, p. 753-761.

Research output: Contribution to journalArticle

Hsu, CC, Wolfgang, CL, Laheru, DA, Pawlik, TM, Swartz, MJ, Winter, JM, Robinson, R, Edil, BH, Narang, AK, Choti, MA, Hruban, RH, Cameron, JL, Schulick, RD & Herman, JM 2012, 'Early Mortality Risk Score: Identification of Poor Outcomes Following Upfront Surgery for Resectable Pancreatic Cancer', Journal of Gastrointestinal Surgery, vol. 16, no. 4, pp. 753-761. https://doi.org/10.1007/s11605-011-1811-4
Hsu, Charles C. ; Wolfgang, Christopher L. ; Laheru, Daniel A. ; Pawlik, Timothy M. ; Swartz, Michael J. ; Winter, Jordan M. ; Robinson, Raymond ; Edil, Barish H. ; Narang, Amol K. ; Choti, Michael A. ; Hruban, Ralph H. ; Cameron, John L. ; Schulick, Richard D. ; Herman, Joseph M. / Early Mortality Risk Score : Identification of Poor Outcomes Following Upfront Surgery for Resectable Pancreatic Cancer. In: Journal of Gastrointestinal Surgery. 2012 ; Vol. 16, No. 4. pp. 753-761.
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abstract = "Background: Identifying pancreatic cancer patients at high risk of early mortality following pancreaticoduodenectomy (PD) is important for treatment decisions in a multidisciplinary setting. This study examines the preoperative predictors of early mortality following PD and combines these variables into an early mortality risk score (EMRS). Methods: Medical records of patients who underwent PD for pancreatic adenocarcinoma at the Johns Hopkins Hospital between 30 August 1993 and 28 February 2005 were reviewed. Cox proportional hazards analysis was performed to identify predictors of early mortality, defined as death at 9 and 12 months. EMRS was constructed from univariate associated risk factors (age >75 years, tumor size ≥3cm, poor differentiation, co-morbid diseases) with each factor assigned 1 point (range of 0-4). EMRS was evaluated as an independent predictor of death at 9 and 12 months. Results: On univariate analysis, risk factors for death at 9 months included age ≥75 years (RR, 1. 6; p =.009), comorbid disease (RR, 1. 5; p = 0. 020), tumor ≥3 cm (RR, 1. 4; P = 0. 050), and poor differentiation (RR, 2. 1; P lt;0. 001). EMRS was associated with early mortality among those who did (p = 0. 038) and did not receive adjuvant treatment (p lt;0. 001). A modified EMRS without tumor differentiation was also associated with early mortality (p lt; 0. 001). Results persisted when reanalyzed using death at 12 months. Conclusions: EMRS may identify patients at risk of early mortality following PD who may be candidates for alternatively sequenced treatment protocols. Prospective validation of this EMRS is needed.",
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AU - Hsu, Charles C.

AU - Wolfgang, Christopher L.

AU - Laheru, Daniel A.

AU - Pawlik, Timothy M.

AU - Swartz, Michael J.

AU - Winter, Jordan M.

AU - Robinson, Raymond

AU - Edil, Barish H.

AU - Narang, Amol K.

AU - Choti, Michael A.

AU - Hruban, Ralph H.

AU - Cameron, John L.

AU - Schulick, Richard D.

AU - Herman, Joseph M.

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N2 - Background: Identifying pancreatic cancer patients at high risk of early mortality following pancreaticoduodenectomy (PD) is important for treatment decisions in a multidisciplinary setting. This study examines the preoperative predictors of early mortality following PD and combines these variables into an early mortality risk score (EMRS). Methods: Medical records of patients who underwent PD for pancreatic adenocarcinoma at the Johns Hopkins Hospital between 30 August 1993 and 28 February 2005 were reviewed. Cox proportional hazards analysis was performed to identify predictors of early mortality, defined as death at 9 and 12 months. EMRS was constructed from univariate associated risk factors (age >75 years, tumor size ≥3cm, poor differentiation, co-morbid diseases) with each factor assigned 1 point (range of 0-4). EMRS was evaluated as an independent predictor of death at 9 and 12 months. Results: On univariate analysis, risk factors for death at 9 months included age ≥75 years (RR, 1. 6; p =.009), comorbid disease (RR, 1. 5; p = 0. 020), tumor ≥3 cm (RR, 1. 4; P = 0. 050), and poor differentiation (RR, 2. 1; P lt;0. 001). EMRS was associated with early mortality among those who did (p = 0. 038) and did not receive adjuvant treatment (p lt;0. 001). A modified EMRS without tumor differentiation was also associated with early mortality (p lt; 0. 001). Results persisted when reanalyzed using death at 12 months. Conclusions: EMRS may identify patients at risk of early mortality following PD who may be candidates for alternatively sequenced treatment protocols. Prospective validation of this EMRS is needed.

AB - Background: Identifying pancreatic cancer patients at high risk of early mortality following pancreaticoduodenectomy (PD) is important for treatment decisions in a multidisciplinary setting. This study examines the preoperative predictors of early mortality following PD and combines these variables into an early mortality risk score (EMRS). Methods: Medical records of patients who underwent PD for pancreatic adenocarcinoma at the Johns Hopkins Hospital between 30 August 1993 and 28 February 2005 were reviewed. Cox proportional hazards analysis was performed to identify predictors of early mortality, defined as death at 9 and 12 months. EMRS was constructed from univariate associated risk factors (age >75 years, tumor size ≥3cm, poor differentiation, co-morbid diseases) with each factor assigned 1 point (range of 0-4). EMRS was evaluated as an independent predictor of death at 9 and 12 months. Results: On univariate analysis, risk factors for death at 9 months included age ≥75 years (RR, 1. 6; p =.009), comorbid disease (RR, 1. 5; p = 0. 020), tumor ≥3 cm (RR, 1. 4; P = 0. 050), and poor differentiation (RR, 2. 1; P lt;0. 001). EMRS was associated with early mortality among those who did (p = 0. 038) and did not receive adjuvant treatment (p lt;0. 001). A modified EMRS without tumor differentiation was also associated with early mortality (p lt; 0. 001). Results persisted when reanalyzed using death at 12 months. Conclusions: EMRS may identify patients at risk of early mortality following PD who may be candidates for alternatively sequenced treatment protocols. Prospective validation of this EMRS is needed.

KW - Early mortality

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KW - Risk score

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